Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent
Human rhinoviruses (HRV) are usually associated with mild respiratory symptoms in children. However, some studies have found that HRV can cause severe disease, especially when the patient is co-infected with a second virus. In this study, 532 nasopharyngeal aspirates (NPAs) were collected over a nin...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2011-05-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300010&lng=en&tlng=en |
| _version_ | 1797713443986341888 |
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| author | Nayhanne Tizzo de Paula Bruno Moreira Carneiro Jonny Yokosawa Guilherme Ramos Oliveira e Freitas Thelma Fátima de Mattos Oliveira Lourenço Faria Costa Hélio Lopes da Silveira Divina Aparecida Oliveira Queiróz |
| author_facet | Nayhanne Tizzo de Paula Bruno Moreira Carneiro Jonny Yokosawa Guilherme Ramos Oliveira e Freitas Thelma Fátima de Mattos Oliveira Lourenço Faria Costa Hélio Lopes da Silveira Divina Aparecida Oliveira Queiróz |
| author_sort | Nayhanne Tizzo de Paula |
| collection | DOAJ |
| description | Human rhinoviruses (HRV) are usually associated with mild respiratory symptoms in children. However, some studies have found that HRV can cause severe disease, especially when the patient is co-infected with a second virus. In this study, 532 nasopharyngeal aspirates (NPAs) were collected over a nine-year period from children at the Clinics Hospital of Uberlândia. The collected NPAs were then tested for HRV RNA using the reverse transcription-polymerase chain reaction. Eighty-three specimens from children diagnosed with lower respiratory tract illness (LRTI) were positive for HRV RNA and were then tested for the presence of eight other respiratory viruses. A second virus was detected in 37.3% (31/83) of the samples. The most frequent clinical diagnosis was bronchiolitis, followed by other LRTI and then pneumonia. The frequency of severe disease in children infected with more than one virus was not significantly different from the frequency of severe disease in children infected with HRV alone. Children infected with both HRV and parainfluenza virus (1.5 m.o.) were significantly younger than those infected by HRV alone (5.0 m.o.) (p = 0.0454). Overall, these results suggest that infection with a second virus does not lead to a higher frequency of severe syndromes in children presenting with LRTI. |
| first_indexed | 2024-03-12T07:36:41Z |
| format | Article |
| id | doaj.art-c9c4ee3d45764b12972825a2013ed9b2 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:36:41Z |
| publishDate | 2011-05-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-c9c4ee3d45764b12972825a2013ed9b22023-09-02T21:28:51ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602011-05-01106331632110.1590/S0074-02762011000300010S0074-02762011000300010Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agentNayhanne Tizzo de Paula0Bruno Moreira Carneiro1Jonny Yokosawa2Guilherme Ramos Oliveira e Freitas3Thelma Fátima de Mattos Oliveira4Lourenço Faria Costa5Hélio Lopes da Silveira6Divina Aparecida Oliveira Queiróz7Universidade Federal de UberlândiaUniversidade Federal de UberlândiaUniversidade Federal de UberlândiaUniversidade Federal de UberlândiaUniversidade Federal de UberlândiaUniversidade Federal de UberlândiaUniversidade Federal de UberlândiaUniversidade Federal de UberlândiaHuman rhinoviruses (HRV) are usually associated with mild respiratory symptoms in children. However, some studies have found that HRV can cause severe disease, especially when the patient is co-infected with a second virus. In this study, 532 nasopharyngeal aspirates (NPAs) were collected over a nine-year period from children at the Clinics Hospital of Uberlândia. The collected NPAs were then tested for HRV RNA using the reverse transcription-polymerase chain reaction. Eighty-three specimens from children diagnosed with lower respiratory tract illness (LRTI) were positive for HRV RNA and were then tested for the presence of eight other respiratory viruses. A second virus was detected in 37.3% (31/83) of the samples. The most frequent clinical diagnosis was bronchiolitis, followed by other LRTI and then pneumonia. The frequency of severe disease in children infected with more than one virus was not significantly different from the frequency of severe disease in children infected with HRV alone. Children infected with both HRV and parainfluenza virus (1.5 m.o.) were significantly younger than those infected by HRV alone (5.0 m.o.) (p = 0.0454). Overall, these results suggest that infection with a second virus does not lead to a higher frequency of severe syndromes in children presenting with LRTI.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300010&lng=en&tlng=enhuman rhinovirusesco-infectionlower respiratory tractyoung children |
| spellingShingle | Nayhanne Tizzo de Paula Bruno Moreira Carneiro Jonny Yokosawa Guilherme Ramos Oliveira e Freitas Thelma Fátima de Mattos Oliveira Lourenço Faria Costa Hélio Lopes da Silveira Divina Aparecida Oliveira Queiróz Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent Memorias do Instituto Oswaldo Cruz human rhinoviruses co-infection lower respiratory tract young children |
| title | Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
| title_full | Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
| title_fullStr | Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
| title_full_unstemmed | Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
| title_short | Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
| title_sort | human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
| topic | human rhinoviruses co-infection lower respiratory tract young children |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300010&lng=en&tlng=en |
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