Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study
Background: Obesity and increased body mass index (BMI) are the known risk factors for adult-onset asthma. Serum free fatty acid (FFA) and other blood lipid levels are generally elevated in patients with obesity and may be involved in the onset of asthma. However, it remains largely unknown. This st...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893023000448 |
| _version_ | 1827390415465086976 |
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| author | Noriyuki Tashima Hisako Matsumoto Kenta Nishi Satoru Terada Mariko Kogo Natsuko Nomura Chie Morimoto Hironobu Sunadome Tadao Nagasaki Tsuyoshi Oguma Yoshinari Nakatsuka Kimihiko Murase Takahisa Kawaguchi Yasuharu Tabara Kazuo Chin Kazuhiro Sonomura Fumihiko Matsuda Toyohiro Hirai |
| author_facet | Noriyuki Tashima Hisako Matsumoto Kenta Nishi Satoru Terada Mariko Kogo Natsuko Nomura Chie Morimoto Hironobu Sunadome Tadao Nagasaki Tsuyoshi Oguma Yoshinari Nakatsuka Kimihiko Murase Takahisa Kawaguchi Yasuharu Tabara Kazuo Chin Kazuhiro Sonomura Fumihiko Matsuda Toyohiro Hirai |
| author_sort | Noriyuki Tashima |
| collection | DOAJ |
| description | Background: Obesity and increased body mass index (BMI) are the known risk factors for adult-onset asthma. Serum free fatty acid (FFA) and other blood lipid levels are generally elevated in patients with obesity and may be involved in the onset of asthma. However, it remains largely unknown. This study aimed to elucidate the relationship between plasma fatty acids and new-onset asthma. Methods: This community-based Nagahama Study in Japan enrolled 9804 residents. We conducted self-reporting questionnaires, lung function tests, and blood tests at baseline and 5 years later as follow-up. At the follow-up, plasma fatty acids were measured using gas chromatography-mass spectrometry. Body composition analysis was also measured at the follow-up. The associations between fatty acids and new-onset asthma were evaluated using a multifaceted approach, including targeted partial least squares discriminant analysis (PLS-DA). Results: In PLS-DA for new-onset asthma, palmitoleic acid was identified as the fatty acid most associated with asthma onset. In the multivariable analysis, higher levels of FFA, palmitoleic acid, or oleic acid were significantly associated with new-onset asthma, independent of other confounding factors. The high body fat percentage itself was not the relevant factor, but showed a positive interaction with plasma palmitoleic acid for new-onset asthma. When stratified by gender, the impacts of higher levels of FFA or palmitoleic acid on new-onset asthma remained significant in females, but not in males. Conclusions: Elevated levels of plasma fatty acids, particularly palmitoleic acid, may be a relevant factor for new-onset asthma. |
| first_indexed | 2024-03-08T16:52:20Z |
| format | Article |
| id | doaj.art-c9c7048b066146c0b96b2dbcafab32b6 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-03-08T16:52:20Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-c9c7048b066146c0b96b2dbcafab32b62024-01-05T04:23:35ZengElsevierAllergology International1323-89302024-01-017316570Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama StudyNoriyuki Tashima0Hisako Matsumoto1Kenta Nishi2Satoru Terada3Mariko Kogo4Natsuko Nomura5Chie Morimoto6Hironobu Sunadome7Tadao Nagasaki8Tsuyoshi Oguma9Yoshinari Nakatsuka10Kimihiko Murase11Takahisa Kawaguchi12Yasuharu Tabara13Kazuo Chin14Kazuhiro Sonomura15Fumihiko Matsuda16Toyohiro Hirai17Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan; Corresponding author. Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kindai University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, JapanCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Division of Sleep Medicine, Department of Sleep Medicine and Respiratory Care, Nihon University of Medicine, Tokyo, JapanCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Life Science Research Center, Technology Research Laboratory, Shimadzu Corporation, Kyoto, JapanCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, JapanBackground: Obesity and increased body mass index (BMI) are the known risk factors for adult-onset asthma. Serum free fatty acid (FFA) and other blood lipid levels are generally elevated in patients with obesity and may be involved in the onset of asthma. However, it remains largely unknown. This study aimed to elucidate the relationship between plasma fatty acids and new-onset asthma. Methods: This community-based Nagahama Study in Japan enrolled 9804 residents. We conducted self-reporting questionnaires, lung function tests, and blood tests at baseline and 5 years later as follow-up. At the follow-up, plasma fatty acids were measured using gas chromatography-mass spectrometry. Body composition analysis was also measured at the follow-up. The associations between fatty acids and new-onset asthma were evaluated using a multifaceted approach, including targeted partial least squares discriminant analysis (PLS-DA). Results: In PLS-DA for new-onset asthma, palmitoleic acid was identified as the fatty acid most associated with asthma onset. In the multivariable analysis, higher levels of FFA, palmitoleic acid, or oleic acid were significantly associated with new-onset asthma, independent of other confounding factors. The high body fat percentage itself was not the relevant factor, but showed a positive interaction with plasma palmitoleic acid for new-onset asthma. When stratified by gender, the impacts of higher levels of FFA or palmitoleic acid on new-onset asthma remained significant in females, but not in males. Conclusions: Elevated levels of plasma fatty acids, particularly palmitoleic acid, may be a relevant factor for new-onset asthma.http://www.sciencedirect.com/science/article/pii/S1323893023000448DyslipidemiaFatty acidNew-onset asthmaObesityPalmitoleic acid |
| spellingShingle | Noriyuki Tashima Hisako Matsumoto Kenta Nishi Satoru Terada Mariko Kogo Natsuko Nomura Chie Morimoto Hironobu Sunadome Tadao Nagasaki Tsuyoshi Oguma Yoshinari Nakatsuka Kimihiko Murase Takahisa Kawaguchi Yasuharu Tabara Kazuo Chin Kazuhiro Sonomura Fumihiko Matsuda Toyohiro Hirai Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study Allergology International Dyslipidemia Fatty acid New-onset asthma Obesity Palmitoleic acid |
| title | Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study |
| title_full | Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study |
| title_fullStr | Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study |
| title_full_unstemmed | Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study |
| title_short | Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study |
| title_sort | evaluation of elevated plasma fatty acids as relevant factors for adult onset asthma the nagahama study |
| topic | Dyslipidemia Fatty acid New-onset asthma Obesity Palmitoleic acid |
| url | http://www.sciencedirect.com/science/article/pii/S1323893023000448 |
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