TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish

TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish

Disease-associated variants of TUBA4A (alpha-tubulin 4A) have recently been identified in familial ALS. Interestingly, a downregulation of TUBA4A protein expression was observed in familial as well as sporadic ALS brain tissue. To investigate whether a decreased TUBA4A expression could be a driving...

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Bibliographic Details
Main Authors: Evelien Van Schoor, Dufie Strubbe, Elke Braems, Jochen Weishaupt, Albert C. Ludolph, Philip Van Damme, Dietmar Rudolf Thal, Valérie Bercier, Ludo Van Den Bosch
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
amyotrophic lateral sclerosis
TUBA4A
microtubules
axonal pathology
zebrafish
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1340240/full

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