Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

Collagens are a primary component of the extracellular matrix and are functional ligands for the inhibitory immune receptor leukocyte-associated immunoglobulin-like receptor (LAIR)-1. LAIR-2 is a secreted protein that can act as a decoy receptor by binding collagen with higher affinity than LAIR-1....

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	M Ines Pascoal Ramos, Linjie Tian, Emma J de Ruiter, Chang Song, Ana Paucarmayta, Akashdip Singh, Eline Elshof, Saskia V Vijver, Jahangheer Shaik, Jason Bosiacki, Zachary Cusumano, Christina Jensen, Nicholas Willumsen, Morten A Karsdal, Linda Liu, Sol Langermann, Stefan Willems, Dallas Flies, Linde Meyaard
Formáid:	Alt
Teanga:	English
Foilsithe / Cruthaithe:	eLife Sciences Publications Ltd 2021-06-01
Sraith:	eLife
Ábhair:	tumor collagen LAIR1
Rochtain ar líne:	https://elifesciences.org/articles/62927

Míreanna comhchosúla

LAIR-1 Limits Neutrophilic Airway Inflammation
de réir: Kuldeep Kumawat, et al.
Foilsithe / Cruthaithe: (2019-04-01)

Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1
de réir: Saskia V. Vijver, et al.
Foilsithe / Cruthaithe: (2021-10-01)

Cancer immunotherapy based on blocking immune suppression mediated by an immune modulator LAIR-1
de réir: Lijun Xu, et al.
Foilsithe / Cruthaithe: (2020-01-01)

445 Blockade of the inhibitory collagen receptor LAIR-1 with NC410, a LAIR2-Fc fusion protein, enhances anti-tumor activity of the bifunctional fusion protein bintrafusp alfa
de réir: Jeffrey Schlom, et al.
Foilsithe / Cruthaithe: (2020-11-01)

694 NC410 is a novel immunomedicine for the treatment of solid tumors
de réir: Linde Meyaard, et al.
Foilsithe / Cruthaithe: (2020-11-01)

Material and Construction Solutions of War Shelters with the Example of Hitler’s Main Headquarters in the Wolf’s Lair
de réir: Szydlowski Rafal, et al.
Foilsithe / Cruthaithe: (2018-01-01)

The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition
de réir: Fu-Lien Hsieh, et al.
Foilsithe / Cruthaithe: (2017-05-01)

Regulation of tumor immunity and immunotherapy by the tumor collagen extracellular matrix
de réir: Dallas B. Flies, et al.
Foilsithe / Cruthaithe: (2023-08-01)

Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1
de réir: Yijia Xie, et al.
Foilsithe / Cruthaithe: (2021-08-01)

LAIR-1 and PECAM-1 function via the same signaling pathway to inhibit GPVI-mediated platelet activation
de réir: Christopher W. Smith, et al.
Foilsithe / Cruthaithe: (2024-08-01)

L’aprenentatge a l’aire lliure a educació infantil i primària a Catalunya
de réir: Núria Mayoral Ambròs, et al.
Foilsithe / Cruthaithe: (2023-11-01)

The Laire affair and the Roman editions of the fifteenth century in the works exchanged between Tommaso Verani and Giovanni Battista Audiffredi
de réir: Lucrezia Signorello
Foilsithe / Cruthaithe: (2022-07-01)

Exposition à court terme à la pollution de l’air en ville : apports et limites des différents types de modèles d’estimation de la pollution
de réir: Gilles Maignant
Foilsithe / Cruthaithe: (2017-07-01)

Effects of LAIR‐1 on hepatocellular carcinoma cell proliferation and invasion via PI3K‐AKT‐mTOR pathway regulation
de réir: Ti Zhou, et al.
Foilsithe / Cruthaithe: (2023-08-01)

487 NC410, a fusion protein of LAIR-2 (Leukocyte Associated Immunoglobulin-like Receptor) with human IgG1 Fc, is safe & tolerable with evidence of immune modulation in subjects with advanced solid tumors
de réir: Ravi Madan, et al.
Foilsithe / Cruthaithe: (2021-11-01)

LAIR-1 agonism as a therapy for acute myeloid leukemia
de réir: Rustin R. Lovewell, et al.
Foilsithe / Cruthaithe: (2023-11-01)

Mechanistic role of FN1 in LAIR-1 mediated downregulation of ovarian cancer cell proliferation
de réir: Huachang Zhang, et al.
Foilsithe / Cruthaithe: (2025-02-01)

De quelques retours de M. Chat : Historiographie politique dans Le fond de l’air est rouge
de réir: Jeremy Hamers, et al.
Foilsithe / Cruthaithe: (2012-10-01)

De quelques retours de M. Chat : Historiographie politique dans Le fond de l’air est rouge
de réir: Jeremy Hamers, et al.
Foilsithe / Cruthaithe: (2012-10-01)

Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation
de réir: Tiago Carvalheiro, et al.
Foilsithe / Cruthaithe: (2020-08-01)

La força de l'aire
de réir: David Jou
Foilsithe / Cruthaithe: (2005-01-01)

Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling enables PD-L1–mediated tumor eradication
de réir: Lucas A. Horn, et al.
Foilsithe / Cruthaithe: (2022-04-01)

Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member.
de réir: Peter J Lenting, et al.
Foilsithe / Cruthaithe: (2010-01-01)

Quand l’air reprend son souffle
de réir: Zoé Brioude
Foilsithe / Cruthaithe: (2021-12-01)

De l’air dans le cerveau
de réir: Hassan Doulhousne, et al.
Foilsithe / Cruthaithe: (2019-11-01)

Les proverbes et l’air du temps
de réir: Sonia Fournet‑Perot
Foilsithe / Cruthaithe: (2013-12-01)

« Quai de Béthune » : l’air des poètes
de réir: Marianne Delranc Gaudric
Foilsithe / Cruthaithe: (2020-06-01)

Serum LAIR-2 is increased in autoimmune thyroid diseases.
de réir: Rita Simone, et al.
Foilsithe / Cruthaithe: (2013-01-01)

Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression
de réir: Myoungsun Son, et al.
Foilsithe / Cruthaithe: (2017-03-01)

Roujan (Hérault). Champs de l’Aire, Saint-Hilaire
de réir: Katia Turrel
Foilsithe / Cruthaithe: (2013-12-01)

L’esprit de parodie dans l’aire romane
de réir: Perle Abbrugiati
Foilsithe / Cruthaithe: (2020-02-01)

La nueva guarida del tango (Tango's New Lair)
de réir: Guillermo Anad
Foilsithe / Cruthaithe: (2008-02-01)

Where myth and archaeology meet: Discovering the Gorgon Medusa's Lair.
de réir: Clive Finlayson, et al.
Foilsithe / Cruthaithe: (2021-01-01)

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
de réir: Kai Xu, et al.
Foilsithe / Cruthaithe: (2021-07-01)

Jalons pour une historiographie de l’aire traductologique francophone
de réir: Yves Gambier
Foilsithe / Cruthaithe: (2023-06-01)

Estudi experimental del percentatge d’oxigen en l’aire
de réir: Xavier Pagés i Segarra, et al.
Foilsithe / Cruthaithe: (2009-06-01)

Blocking LAIR1 signaling in immune cells inhibits tumor development
de réir: Jingjing Xie, et al.
Foilsithe / Cruthaithe: (2022-09-01)

L’aire sacrée de Baal Hammon – Saturne à Dougga
de réir: Samir Aounallah, et al.
Foilsithe / Cruthaithe: (2020-12-01)

Structure économique et croissance dans l’aire métropolitaine bruxelloise
de réir: Didier Baudewyns
Foilsithe / Cruthaithe: (2007-02-01)

Correction: Where myth and archaeology meet: Discovering the Gorgon Medusa's Lair.
de réir: PLOS ONE Staff
Foilsithe / Cruthaithe: (2021-01-01)