Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

Collagens are a primary component of the extracellular matrix and are functional ligands for the inhibitory immune receptor leukocyte-associated immunoglobulin-like receptor (LAIR)-1. LAIR-2 is a secreted protein that can act as a decoy receptor by binding collagen with higher affinity than LAIR-1....

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Manylion Llyfryddiaeth
Prif Awduron: M Ines Pascoal Ramos, Linjie Tian, Emma J de Ruiter, Chang Song, Ana Paucarmayta, Akashdip Singh, Eline Elshof, Saskia V Vijver, Jahangheer Shaik, Jason Bosiacki, Zachary Cusumano, Christina Jensen, Nicholas Willumsen, Morten A Karsdal, Linda Liu, Sol Langermann, Stefan Willems, Dallas Flies, Linde Meyaard
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: eLife Sciences Publications Ltd 2021-06-01
Cyfres:eLife
Pynciau:
tumor
collagen
LAIR1
Mynediad Ar-lein:https://elifesciences.org/articles/62927

Rhyngrwyd

https://elifesciences.org/articles/62927

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