The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice
Abstract Background Cordia myxa L. (Boraginaceae) is widely distributed in tropical regions and it’s fruits, leaves and stem bark have been utilized in folk medicine for treating trypanosomiasis caused by Trypanosoma cruzi. A population-based study showed that T. cruzi infection is associated with c...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Complementary Medicine and Therapies |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12906-022-03693-z |
| _version_ | 1818499065025921024 |
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| author | Gülsen Kendir Ho Jung Bae Jihyun Kim Yongwoo Jeong Hyo Jeoung Bae Keontae Park Xingquan Yang Young-jin Cho Ji-Young Kim Seo Yun Jung Ayşegül Köroğlu Dae Sik Jang Jong Hoon Ryu |
| author_facet | Gülsen Kendir Ho Jung Bae Jihyun Kim Yongwoo Jeong Hyo Jeoung Bae Keontae Park Xingquan Yang Young-jin Cho Ji-Young Kim Seo Yun Jung Ayşegül Köroğlu Dae Sik Jang Jong Hoon Ryu |
| author_sort | Gülsen Kendir |
| collection | DOAJ |
| description | Abstract Background Cordia myxa L. (Boraginaceae) is widely distributed in tropical regions and it’s fruits, leaves and stem bark have been utilized in folk medicine for treating trypanosomiasis caused by Trypanosoma cruzi. A population-based study showed that T. cruzi infection is associated with cognitive impairments. Therefore, if C. myxa has ameliorating activities on cognitive function, it would be useful for both T. cruzi infection and cognitive impairments. Methods In this study, we evaluated the effects of an ethanol extract of leaves of C. myxa (ELCM) on memory impairments and sensorimotor gating deficits in mice. The phosphorylation level of protein was observed by the Western blot analysis. Results The administration of ELCM significantly attenuated scopolamine-induced cognitive dysfunction in mice, as measured by passive avoidance test and novel object recognition test. Additionally, in the acoustic startle response test, we observed that the administration of ELCM ameliorated MK-801-induced prepulse inhibition deficits. We found that these behavioral outcomes were related with increased levels of phosphorylation phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK-3β) in the cortex and extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB) in the hippocampus by western blot analysis. Conclusions These results suggest that ELCM would be a potential candidate for treating cognitive dysfunction and sensorimotor gating deficits observed in individuals with neurodegenerative diseases. |
| first_indexed | 2024-12-10T20:24:11Z |
| format | Article |
| id | doaj.art-c9cbc754bb9040c9951ca57b2e6ef689 |
| institution | Directory Open Access Journal |
| issn | 2662-7671 |
| language | English |
| last_indexed | 2024-12-10T20:24:11Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary Medicine and Therapies |
| spelling | doaj.art-c9cbc754bb9040c9951ca57b2e6ef6892022-12-22T01:34:56ZengBMCBMC Complementary Medicine and Therapies2662-76712022-08-0122111110.1186/s12906-022-03693-zThe effects of the ethanol extract of Cordia myxa leaves on the cognitive function in miceGülsen Kendir0Ho Jung Bae1Jihyun Kim2Yongwoo Jeong3Hyo Jeoung Bae4Keontae Park5Xingquan Yang6Young-jin Cho7Ji-Young Kim8Seo Yun Jung9Ayşegül Köroğlu10Dae Sik Jang11Jong Hoon Ryu12Department of Pharmaceutical Botany, Faculty of Pharmacy, Süleyman Demirel UniversityAgriculture and Life Science Research Institute, Kangwon National UniversityDepartment of Life and Nanopharmaceutical Science, Kyung Hee UniversityDepartment of Life and Nanopharmaceutical Science, Kyung Hee UniversityDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee UniversityDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee UniversityDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee UniversityDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee UniversityDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee UniversityDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee UniversityDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Ankara UniversityDepartment of Life and Nanopharmaceutical Science, Kyung Hee UniversityDepartment of Life and Nanopharmaceutical Science, Kyung Hee UniversityAbstract Background Cordia myxa L. (Boraginaceae) is widely distributed in tropical regions and it’s fruits, leaves and stem bark have been utilized in folk medicine for treating trypanosomiasis caused by Trypanosoma cruzi. A population-based study showed that T. cruzi infection is associated with cognitive impairments. Therefore, if C. myxa has ameliorating activities on cognitive function, it would be useful for both T. cruzi infection and cognitive impairments. Methods In this study, we evaluated the effects of an ethanol extract of leaves of C. myxa (ELCM) on memory impairments and sensorimotor gating deficits in mice. The phosphorylation level of protein was observed by the Western blot analysis. Results The administration of ELCM significantly attenuated scopolamine-induced cognitive dysfunction in mice, as measured by passive avoidance test and novel object recognition test. Additionally, in the acoustic startle response test, we observed that the administration of ELCM ameliorated MK-801-induced prepulse inhibition deficits. We found that these behavioral outcomes were related with increased levels of phosphorylation phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK-3β) in the cortex and extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB) in the hippocampus by western blot analysis. Conclusions These results suggest that ELCM would be a potential candidate for treating cognitive dysfunction and sensorimotor gating deficits observed in individuals with neurodegenerative diseases.https://doi.org/10.1186/s12906-022-03693-zCordia myxaAlzheimer’s diseaseRecognition memorySensorimotor gatingPI3K-Akt-GSK3β signalingERK-CREB signaling |
| spellingShingle | Gülsen Kendir Ho Jung Bae Jihyun Kim Yongwoo Jeong Hyo Jeoung Bae Keontae Park Xingquan Yang Young-jin Cho Ji-Young Kim Seo Yun Jung Ayşegül Köroğlu Dae Sik Jang Jong Hoon Ryu The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice BMC Complementary Medicine and Therapies Cordia myxa Alzheimer’s disease Recognition memory Sensorimotor gating PI3K-Akt-GSK3β signaling ERK-CREB signaling |
| title | The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice |
| title_full | The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice |
| title_fullStr | The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice |
| title_full_unstemmed | The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice |
| title_short | The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice |
| title_sort | effects of the ethanol extract of cordia myxa leaves on the cognitive function in mice |
| topic | Cordia myxa Alzheimer’s disease Recognition memory Sensorimotor gating PI3K-Akt-GSK3β signaling ERK-CREB signaling |
| url | https://doi.org/10.1186/s12906-022-03693-z |
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