Preincisional administration of intravenous or subcutaneous infiltration of low-dose ketamine suppresses postoperative pain after appendectomy
Azim Honarmand, Mohammadreza Safavi, Hasan KarakyAnesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, IranBackground: Ketamine, an N-methyl-D-aspartate receptor antagonist, can suppress hyperalgesia and allodynia. The purpose of the present study was to...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2011-12-01
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| Series: | Journal of Pain Research |
| Online Access: | http://www.dovepress.com/preincisional-administration-of-intravenous-or-subcutaneous-infiltrati-a8985 |
| _version_ | 1811264230885687296 |
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| author | Honarm A Safavi M Karaky H |
| author_facet | Honarm A Safavi M Karaky H |
| author_sort | Honarm |
| collection | DOAJ |
| description | Azim Honarmand, Mohammadreza Safavi, Hasan KarakyAnesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, IranBackground: Ketamine, an N-methyl-D-aspartate receptor antagonist, can suppress hyperalgesia and allodynia. The purpose of the present study was to evaluate the clinical efficacy of preincisional intravenous or subcutaneous infiltration of ketamine for postoperative pain relief after appendectomy.Methods: Ninety patients, aged 18–60 years, scheduled for appendectomy was enrolled in this study. Patients were divided into three groups of 30 each and received subcutaneous infiltration of ketamine 0.5 mg/kg (KS), intravenous ketamine 0.5 mg/kg (KI), or subcutaneous infiltration of normal saline 3 mL (C) before surgery. Visual analog scale (VAS) values and analgesic consumption were evaluated for 24 hours after surgery.Results: VAS scores were significantly lower at the time of arrival in the recovery room, and at 10, 20, and 30 minutes thereafter in group KI and group KS compared with group C (P < 0.05). VAS scores were not significantly different between group KI and group KS at these intervals. Postoperative VAS scores were significantly lower at 6, 12, 18, and 24 hours in group KI compared with group C (P < 0.05). In group KS, the postoperative VAS score was significantly lower at 6 hours (P < 0.05). VAS scores were significantly lower at 12, 18, and 24 hours after surgery in group KI compared with group KS (P < 0.05).Conclusion: A 0.5 mg/kg dose of ketamine given at approximately 15 minutes before surgery by the intravenous route provided analgesia for 24 hours after surgery in patients undergoing appendectomy.Keywords: pain, postoperative, analgesia, ketamine, appendectomy |
| first_indexed | 2024-04-12T19:59:22Z |
| format | Article |
| id | doaj.art-c9cc5e2ba37a4705b330cf497ca87c2d |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-04-12T19:59:22Z |
| publishDate | 2011-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-c9cc5e2ba37a4705b330cf497ca87c2d2022-12-22T03:18:35ZengDove Medical PressJournal of Pain Research1178-70902011-12-012012default16Preincisional administration of intravenous or subcutaneous infiltration of low-dose ketamine suppresses postoperative pain after appendectomyHonarmASafavi MKaraky HAzim Honarmand, Mohammadreza Safavi, Hasan KarakyAnesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, IranBackground: Ketamine, an N-methyl-D-aspartate receptor antagonist, can suppress hyperalgesia and allodynia. The purpose of the present study was to evaluate the clinical efficacy of preincisional intravenous or subcutaneous infiltration of ketamine for postoperative pain relief after appendectomy.Methods: Ninety patients, aged 18–60 years, scheduled for appendectomy was enrolled in this study. Patients were divided into three groups of 30 each and received subcutaneous infiltration of ketamine 0.5 mg/kg (KS), intravenous ketamine 0.5 mg/kg (KI), or subcutaneous infiltration of normal saline 3 mL (C) before surgery. Visual analog scale (VAS) values and analgesic consumption were evaluated for 24 hours after surgery.Results: VAS scores were significantly lower at the time of arrival in the recovery room, and at 10, 20, and 30 minutes thereafter in group KI and group KS compared with group C (P < 0.05). VAS scores were not significantly different between group KI and group KS at these intervals. Postoperative VAS scores were significantly lower at 6, 12, 18, and 24 hours in group KI compared with group C (P < 0.05). In group KS, the postoperative VAS score was significantly lower at 6 hours (P < 0.05). VAS scores were significantly lower at 12, 18, and 24 hours after surgery in group KI compared with group KS (P < 0.05).Conclusion: A 0.5 mg/kg dose of ketamine given at approximately 15 minutes before surgery by the intravenous route provided analgesia for 24 hours after surgery in patients undergoing appendectomy.Keywords: pain, postoperative, analgesia, ketamine, appendectomyhttp://www.dovepress.com/preincisional-administration-of-intravenous-or-subcutaneous-infiltrati-a8985 |
| spellingShingle | Honarm A Safavi M Karaky H Preincisional administration of intravenous or subcutaneous infiltration of low-dose ketamine suppresses postoperative pain after appendectomy Journal of Pain Research |
| title | Preincisional administration of intravenous or subcutaneous infiltration of low-dose ketamine suppresses postoperative pain after appendectomy |
| title_full | Preincisional administration of intravenous or subcutaneous infiltration of low-dose ketamine suppresses postoperative pain after appendectomy |
| title_fullStr | Preincisional administration of intravenous or subcutaneous infiltration of low-dose ketamine suppresses postoperative pain after appendectomy |
| title_full_unstemmed | Preincisional administration of intravenous or subcutaneous infiltration of low-dose ketamine suppresses postoperative pain after appendectomy |
| title_short | Preincisional administration of intravenous or subcutaneous infiltration of low-dose ketamine suppresses postoperative pain after appendectomy |
| title_sort | preincisional administration of intravenous or subcutaneous infiltration of low dose ketamine suppresses postoperative pain after appendectomy |
| url | http://www.dovepress.com/preincisional-administration-of-intravenous-or-subcutaneous-infiltrati-a8985 |
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