Healthy aging—would cytotoxic T lymphocytes stand out?
Senescent cells (SnCs) accumulate in multiple tissue types with the process of individual aging, hindering tissue renewal and driving multiple aging-related disorders. Aside from senescence-associated secretory phenotype (SASP) neutralization and senolytics, there is an emerging senolysis strategy t...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2023-10-01
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Series: | Cell Death Discovery |
Online Access: | https://doi.org/10.1038/s41420-023-01699-1 |
Summary: | Senescent cells (SnCs) accumulate in multiple tissue types with the process of individual aging, hindering tissue renewal and driving multiple aging-related disorders. Aside from senescence-associated secretory phenotype (SASP) neutralization and senolytics, there is an emerging senolysis strategy to eliminate SnCs by mobilizing the immunosurveillance function of cytotoxic T lymphocytes (CTLs). |
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ISSN: | 2058-7716 |