| Summary: | <p>Abstract</p> <p>Background</p> <p>Cytochrome <it>P</it>450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones.</p> <p>Methods</p> <p>To investigate if common variants of <it>CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1 </it>and <it>CYP19A1 </it>influence CRC risk we genotyped 2,575 CRC cases and 2,707 controls for 20 single nucleotide polymorphisms (SNPs) that have not previously been shown to have functional consequence within these genes.</p> <p>Results</p> <p>There was a suggestion of increased risk, albeit insignificant after correction for multiple testing, of CRC for individuals homozygous for <it>CYP1B1 </it>rs162558 and heterozygous for <it>CYP1A2 </it>rs2069522 (odds ratio [OR] = 1.36, 95% confidence interval [CI]: 1.03–1.80 and OR = 1.34, 95% CI: 1.00–1.79 respectively).</p> <p>Conclusion</p> <p>This study provides some support for polymorphic variation in <it>CYP1A2 </it>and <it>CYP1B1 </it>playing a role in CRC susceptibility.</p>
|
|---|