Short chain fatty acids, a possible treatment option for autoimmune diseases
Gut microbiota can interact with the immune system through its metabolites. Short-chain fatty acids (SCFAs), as one of the most abundant metabolites of the resident gut microbiota play an important role in this crosstalk. SCFAs (acetate, propionate, and butyrate) regulate nearly every type of immune...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223005528 |
| _version_ | 1797822145681686528 |
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| author | Faezeh Golpour Mehrsa Abbasi-Alaei Fatemeh Babaei Mohammadreza Mirzababaei Siavash Parvardeh Ghazaleh Mohammadi Marjan Nassiri-Asl |
| author_facet | Faezeh Golpour Mehrsa Abbasi-Alaei Fatemeh Babaei Mohammadreza Mirzababaei Siavash Parvardeh Ghazaleh Mohammadi Marjan Nassiri-Asl |
| author_sort | Faezeh Golpour |
| collection | DOAJ |
| description | Gut microbiota can interact with the immune system through its metabolites. Short-chain fatty acids (SCFAs), as one of the most abundant metabolites of the resident gut microbiota play an important role in this crosstalk. SCFAs (acetate, propionate, and butyrate) regulate nearly every type of immune cell in the gut’s immune cell repertoire regarding their development and function. SCFAs work through several pathways to impose protection towards colonic health and against local or systemic inflammation. Additionally, SCFAs play a role in the regulation of immune or non-immune pathways that can slow the development of autoimmunity either systematically or in situ. The present study aims to summarize the current knowledge on the immunomodulatory roles of SCFAs and the association between the SCFAs and autoimmune disorders such as celiac disease (CD), inflammatory bowel disease (IBD), rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE), type 1 diabetes (T1D) and other immune-mediated diseases, uncovering a brand-new therapeutic possibility to prevent or treat autoimmunity. |
| first_indexed | 2024-03-13T10:03:36Z |
| format | Article |
| id | doaj.art-c9cefe8cc6544db09db7c88438c70d16 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T10:03:36Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-c9cefe8cc6544db09db7c88438c70d162023-05-23T04:21:00ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-07-01163114763Short chain fatty acids, a possible treatment option for autoimmune diseasesFaezeh Golpour0Mehrsa Abbasi-Alaei1Fatemeh Babaei2Mohammadreza Mirzababaei3Siavash Parvardeh4Ghazaleh Mohammadi5Marjan Nassiri-Asl6School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Clinical Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranCellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran; Department of Molecular Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran; Corresponding author at: Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Correspondence to: Department of Pharmacology and Neurobiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. P.O. Box 19839-63113.Gut microbiota can interact with the immune system through its metabolites. Short-chain fatty acids (SCFAs), as one of the most abundant metabolites of the resident gut microbiota play an important role in this crosstalk. SCFAs (acetate, propionate, and butyrate) regulate nearly every type of immune cell in the gut’s immune cell repertoire regarding their development and function. SCFAs work through several pathways to impose protection towards colonic health and against local or systemic inflammation. Additionally, SCFAs play a role in the regulation of immune or non-immune pathways that can slow the development of autoimmunity either systematically or in situ. The present study aims to summarize the current knowledge on the immunomodulatory roles of SCFAs and the association between the SCFAs and autoimmune disorders such as celiac disease (CD), inflammatory bowel disease (IBD), rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE), type 1 diabetes (T1D) and other immune-mediated diseases, uncovering a brand-new therapeutic possibility to prevent or treat autoimmunity.http://www.sciencedirect.com/science/article/pii/S0753332223005528Short-chain fatty acidAutoimmunityButyrateAcetatePropionateAutoimmune disease |
| spellingShingle | Faezeh Golpour Mehrsa Abbasi-Alaei Fatemeh Babaei Mohammadreza Mirzababaei Siavash Parvardeh Ghazaleh Mohammadi Marjan Nassiri-Asl Short chain fatty acids, a possible treatment option for autoimmune diseases Biomedicine & Pharmacotherapy Short-chain fatty acid Autoimmunity Butyrate Acetate Propionate Autoimmune disease |
| title | Short chain fatty acids, a possible treatment option for autoimmune diseases |
| title_full | Short chain fatty acids, a possible treatment option for autoimmune diseases |
| title_fullStr | Short chain fatty acids, a possible treatment option for autoimmune diseases |
| title_full_unstemmed | Short chain fatty acids, a possible treatment option for autoimmune diseases |
| title_short | Short chain fatty acids, a possible treatment option for autoimmune diseases |
| title_sort | short chain fatty acids a possible treatment option for autoimmune diseases |
| topic | Short-chain fatty acid Autoimmunity Butyrate Acetate Propionate Autoimmune disease |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223005528 |
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