Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics
Cardiovascular diseases (CVDs) represent a significant challenge in global health, demanding advancements in diagnostic modalities. This review delineates the progressive and restrictive facets of nanomaterial-based biosensors in the context of detecting N-terminal pro-B-type natriuretic peptide (NT...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/14/2/153 |
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| author | Yen-Yi Lee Balasubramanian Sriram Sea-Fue Wang Sakthivel Kogularasu Guo-Ping Chang-Chien |
| author_facet | Yen-Yi Lee Balasubramanian Sriram Sea-Fue Wang Sakthivel Kogularasu Guo-Ping Chang-Chien |
| author_sort | Yen-Yi Lee |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) represent a significant challenge in global health, demanding advancements in diagnostic modalities. This review delineates the progressive and restrictive facets of nanomaterial-based biosensors in the context of detecting N-terminal pro-B-type natriuretic peptide (NT-proBNP), an indispensable biomarker for CVD prognosis. It scrutinizes the escalation in diagnostic sensitivity and specificity attributable to the incorporation of novel nanomaterials such as graphene derivatives, quantum dots, and metallic nanoparticles, and how these enhancements contribute to reducing detection thresholds and augmenting diagnostic fidelity in heart failure (HF). Despite these technological strides, the review articulates pivotal challenges impeding the clinical translation of these biosensors, including the attainment of clinical-grade sensitivity, the substantial costs associated with synthesizing and functionalizing nanomaterials, and their pragmatic deployment across varied healthcare settings. The necessity for intensified research into the synthesis and functionalization of nanomaterials, strategies to economize production, and amelioration of biosensor durability and ease of use is accentuated. Regulatory hurdles in clinical integration are also contemplated. In summation, the review accentuates the transformative potential of nanomaterial-based biosensors in HF diagnostics and emphasizes critical avenues of research requisite to surmount current impediments and harness the full spectrum of these avant-garde diagnostic instruments. |
| first_indexed | 2024-03-08T10:39:45Z |
| format | Article |
| id | doaj.art-c9d1b0f530854859bf1611923105ccfb |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-08T10:39:45Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-c9d1b0f530854859bf1611923105ccfb2024-01-26T17:58:17ZengMDPI AGNanomaterials2079-49912024-01-0114215310.3390/nano14020153Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease DiagnosticsYen-Yi Lee0Balasubramanian Sriram1Sea-Fue Wang2Sakthivel Kogularasu3Guo-Ping Chang-Chien4Institute of Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 833301, TaiwanDepartment of Materials and Mineral Resources Engineering, National Taipei University of Technology, Taipei 10608, TaiwanDepartment of Materials and Mineral Resources Engineering, National Taipei University of Technology, Taipei 10608, TaiwanSuper Micro Mass Research and Technology Center, Cheng Shiu University, Kaohsiung 833301, TaiwanInstitute of Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 833301, TaiwanCardiovascular diseases (CVDs) represent a significant challenge in global health, demanding advancements in diagnostic modalities. This review delineates the progressive and restrictive facets of nanomaterial-based biosensors in the context of detecting N-terminal pro-B-type natriuretic peptide (NT-proBNP), an indispensable biomarker for CVD prognosis. It scrutinizes the escalation in diagnostic sensitivity and specificity attributable to the incorporation of novel nanomaterials such as graphene derivatives, quantum dots, and metallic nanoparticles, and how these enhancements contribute to reducing detection thresholds and augmenting diagnostic fidelity in heart failure (HF). Despite these technological strides, the review articulates pivotal challenges impeding the clinical translation of these biosensors, including the attainment of clinical-grade sensitivity, the substantial costs associated with synthesizing and functionalizing nanomaterials, and their pragmatic deployment across varied healthcare settings. The necessity for intensified research into the synthesis and functionalization of nanomaterials, strategies to economize production, and amelioration of biosensor durability and ease of use is accentuated. Regulatory hurdles in clinical integration are also contemplated. In summation, the review accentuates the transformative potential of nanomaterial-based biosensors in HF diagnostics and emphasizes critical avenues of research requisite to surmount current impediments and harness the full spectrum of these avant-garde diagnostic instruments.https://www.mdpi.com/2079-4991/14/2/153nanomaterialsbiomarkersN-terminal pro-B-type natriuretic peptidecardiovascular diseasesbiosensors |
| spellingShingle | Yen-Yi Lee Balasubramanian Sriram Sea-Fue Wang Sakthivel Kogularasu Guo-Ping Chang-Chien Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics Nanomaterials nanomaterials biomarkers N-terminal pro-B-type natriuretic peptide cardiovascular diseases biosensors |
| title | Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics |
| title_full | Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics |
| title_fullStr | Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics |
| title_full_unstemmed | Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics |
| title_short | Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics |
| title_sort | advanced nanomaterial based biosensors for n terminal pro brain natriuretic peptide biomarker detection progress and future challenges in cardiovascular disease diagnostics |
| topic | nanomaterials biomarkers N-terminal pro-B-type natriuretic peptide cardiovascular diseases biosensors |
| url | https://www.mdpi.com/2079-4991/14/2/153 |
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