Regulatory Role and Potential Importance of GDF-8 in Ovarian Reproductive Activity

Regulatory Role and Potential Importance of GDF-8 in Ovarian Reproductive Activity

Growth differentiation factor-8 (GDF-8) is a member of the transforming growth factor-beta superfamily. Studies in vitro and in vivo have shown GDF-8 to be involved in the physiology and pathology of ovarian reproductive functions. In vitro experiments using a granulosa-cell model have demonstrated...

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Bibliographic Details
Main Authors: Xiaoling Zheng, Yongquan Zheng, Dongxu Qin, Yao Yao, Xiao Zhang, Yunchun Zhao, Caihong Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Endocrinology
Subjects:
GDF-8
PCOS (polycystic ovarian syndrome)
ovarian response
pregnancy outcome
granulosa cells (GC)
SMAD signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.878069/full

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