ANTIMICROBIAL THERAPY DURING CANCER TREATMENT: A CASE REPORT
Introduction. Penile cancer (pc) is a rare cancer. The standardized incidence rate of pc in russia is 0.82 cases per 100,000 males. On average, 58 % of patients (20–96 %) with pc have a local infection process: tumor decay, the presence of erosion, tumor ulceration, inflammatory changes in regional...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2021-08-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/1879 |
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| author | Z. V. Grigoryevskaya V. B. Matveev D. A. Sergeev I. V. Tereshchenko V. D. Vinnikova V. A. Vershinskaya I. N. Petukhova N. S. Bagirova N. V. Dmitrieva |
| author_facet | Z. V. Grigoryevskaya V. B. Matveev D. A. Sergeev I. V. Tereshchenko V. D. Vinnikova V. A. Vershinskaya I. N. Petukhova N. S. Bagirova N. V. Dmitrieva |
| author_sort | Z. V. Grigoryevskaya |
| collection | DOAJ |
| description | Introduction. Penile cancer (pc) is a rare cancer. The standardized incidence rate of pc in russia is 0.82 cases per 100,000 males. On average, 58 % of patients (20–96 %) with pc have a local infection process: tumor decay, the presence of erosion, tumor ulceration, inflammatory changes in regional lymph nodes, etc. During hospitalization nosocomial pathogens may be possible causes of infection in ulcerative lesions.The aim of the study was to present the results of the treatment of tumor ulcer in a patient with penile cancer infected with multiresistant acinetobacter baumannii and klebsiella pneumoniae.Material and methods. We present a clinical observation of 54-year-old patient diagnosed with penile cancer pt4n3m0, with ulceration of the tumor, localized at the root of the penis and ulceration of metastatic lymph nodes in the left inguinal region and subsequent infection with highly resistant nosocomial microorganisms.Results. The patient received 6 courses of paclitaxel, ifosfamide and cisplatin with clinical effect, such as significant reduction of the tumor and therapeutic pathomorphosis of 3-rd degree. Then ileo-inguinal lymphadenectomy was performed on the left. A few months later the tumor continued to grow in the left groin area. During the 2nd line of chemotherapy (cisplatin, docetaxel and capecitabine), the patient had grade iii–iv neutropenia, febrile neutropenia. High fever and localized infection in the area of tumor ulceration with multiresistant hospital microorganisms was detected. Combined antibiotic therapy had temporary effect. After isolation of multiresistant carbapenemresistant k. Pneumoniae from the ulcer, the patient was prescribed ceftazidim/avibactam 2.5 g 3 times a day. Clinical effect, such as defervescence and significant reduction of the ulceration zone was seen subsequently.Conclusion. Etiotropic antibacterial therapy of the infected tumor ulcer resulted in a significant reduction in the manifestation of the infection process, allowing antitumor therapy to be continued, as well as surgery to be performed. |
| first_indexed | 2024-04-10T01:52:34Z |
| format | Article |
| id | doaj.art-c9d3db656c6048aa8992c3762cb08578 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:52:34Z |
| publishDate | 2021-08-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-c9d3db656c6048aa8992c3762cb085782023-03-13T09:05:54ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682021-08-0120416016510.21294/1814-4861-2021-20-4-160-165894ANTIMICROBIAL THERAPY DURING CANCER TREATMENT: A CASE REPORTZ. V. Grigoryevskaya0V. B. Matveev1D. A. Sergeev2I. V. Tereshchenko3V. D. Vinnikova4V. A. Vershinskaya5I. N. Petukhova6N. S. Bagirova7N. V. Dmitrieva8ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииIntroduction. Penile cancer (pc) is a rare cancer. The standardized incidence rate of pc in russia is 0.82 cases per 100,000 males. On average, 58 % of patients (20–96 %) with pc have a local infection process: tumor decay, the presence of erosion, tumor ulceration, inflammatory changes in regional lymph nodes, etc. During hospitalization nosocomial pathogens may be possible causes of infection in ulcerative lesions.The aim of the study was to present the results of the treatment of tumor ulcer in a patient with penile cancer infected with multiresistant acinetobacter baumannii and klebsiella pneumoniae.Material and methods. We present a clinical observation of 54-year-old patient diagnosed with penile cancer pt4n3m0, with ulceration of the tumor, localized at the root of the penis and ulceration of metastatic lymph nodes in the left inguinal region and subsequent infection with highly resistant nosocomial microorganisms.Results. The patient received 6 courses of paclitaxel, ifosfamide and cisplatin with clinical effect, such as significant reduction of the tumor and therapeutic pathomorphosis of 3-rd degree. Then ileo-inguinal lymphadenectomy was performed on the left. A few months later the tumor continued to grow in the left groin area. During the 2nd line of chemotherapy (cisplatin, docetaxel and capecitabine), the patient had grade iii–iv neutropenia, febrile neutropenia. High fever and localized infection in the area of tumor ulceration with multiresistant hospital microorganisms was detected. Combined antibiotic therapy had temporary effect. After isolation of multiresistant carbapenemresistant k. Pneumoniae from the ulcer, the patient was prescribed ceftazidim/avibactam 2.5 g 3 times a day. Clinical effect, such as defervescence and significant reduction of the ulceration zone was seen subsequently.Conclusion. Etiotropic antibacterial therapy of the infected tumor ulcer resulted in a significant reduction in the manifestation of the infection process, allowing antitumor therapy to be continued, as well as surgery to be performed.https://www.siboncoj.ru/jour/article/view/1879рак полового членаacinetobacter baumanniklebsiella pneumoniaeмультирезистентный штаммкарбапенем-резистентный штаммцефтазидим/авибактамнозокомиальные инфекцииантибактериальная терапия |
| spellingShingle | Z. V. Grigoryevskaya V. B. Matveev D. A. Sergeev I. V. Tereshchenko V. D. Vinnikova V. A. Vershinskaya I. N. Petukhova N. S. Bagirova N. V. Dmitrieva ANTIMICROBIAL THERAPY DURING CANCER TREATMENT: A CASE REPORT Сибирский онкологический журнал рак полового члена acinetobacter baumanni klebsiella pneumoniae мультирезистентный штамм карбапенем-резистентный штамм цефтазидим/авибактам нозокомиальные инфекции антибактериальная терапия |
| title | ANTIMICROBIAL THERAPY DURING CANCER TREATMENT: A CASE REPORT |
| title_full | ANTIMICROBIAL THERAPY DURING CANCER TREATMENT: A CASE REPORT |
| title_fullStr | ANTIMICROBIAL THERAPY DURING CANCER TREATMENT: A CASE REPORT |
| title_full_unstemmed | ANTIMICROBIAL THERAPY DURING CANCER TREATMENT: A CASE REPORT |
| title_short | ANTIMICROBIAL THERAPY DURING CANCER TREATMENT: A CASE REPORT |
| title_sort | antimicrobial therapy during cancer treatment a case report |
| topic | рак полового члена acinetobacter baumanni klebsiella pneumoniae мультирезистентный штамм карбапенем-резистентный штамм цефтазидим/авибактам нозокомиальные инфекции антибактериальная терапия |
| url | https://www.siboncoj.ru/jour/article/view/1879 |
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