Quantification of the renal sinus fat and exploration of its relationship with ectopic fat deposition in normal subjects using MRI fat fraction mapping
PurposeTo determine the renal sinus fat (RSF) volume and fat fraction (FF) in normal Chinese subjects using MRI fat fraction mapping and to explore their associations with age, gender, body mass index (BMI) and ectopic fat deposition.MethodsA total of 126 subjects were included in the analysis. RSF...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1187781/full |
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| author | Qin-He Zhang Li-Hua Chen Qi An Peng Pi Yi-Fan Dong Ying Zhao Nan Wang Xin Fang Ren-Wang Pu Qing-Wei Song Liang-Jie Lin Jing-Hong Liu Ai-Lian Liu |
| author_facet | Qin-He Zhang Li-Hua Chen Qi An Peng Pi Yi-Fan Dong Ying Zhao Nan Wang Xin Fang Ren-Wang Pu Qing-Wei Song Liang-Jie Lin Jing-Hong Liu Ai-Lian Liu |
| author_sort | Qin-He Zhang |
| collection | DOAJ |
| description | PurposeTo determine the renal sinus fat (RSF) volume and fat fraction (FF) in normal Chinese subjects using MRI fat fraction mapping and to explore their associations with age, gender, body mass index (BMI) and ectopic fat deposition.MethodsA total of 126 subjects were included in the analysis. RSF volume and FF, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area, and hepatic and pancreatic FFs were measured for each subject. The comparisons in gender were determined using two-tailed t-tests or the nonparametric Mann-Whitney U-test for normally or non-normally distributed data for continuous variables and the chi-square test for categorical variables. Comparisons of RFS volume and FF between right and left kidneys were determined using paired sample t-tests. Multivariable logistic models were performed to confirm whether RSF differences between men and women are independent of VAT or SAT area. When parameters were normally distributed, the Pearson correlation coefficient was used; otherwise, the Spearman correlation coefficient was applied.ResultsThe RSF volumes (cm3) of both kidneys in men (26.86 ± 8.81 for right and 31.62 ± 10.32 for left kidneys) were significantly bigger than those of women (21.47 ± 6.90 for right and 26.03 ± 8.55 for left kidneys) (P < 0.05). The RSF FFs (%) of both kidneys in men (28.33 ± 6.73 for right and 31.21 ± 6.29 for left kidneys) were significantly higher than those of the women (23.82 ± 7.74 for right and 27.92 ± 8.15 for left kidneys) (P < 0.05). The RSF differences between men and women are independent of SAT area and dependent of VAT area (except for right RSF volume). In addition, the RSF volumes and FFs in both kidneys in the overall subjects show significant correlations with age, BMI, VAT area, hepatic fat fraction and pancreatic fat fraction (P < 0.05). However, the patterns of these correlations varied by gender. The RSF volume and FF of left kidney were significantly larger than those of the right kidney (P < 0.05).ConclusionThe association between renal sinus fat and ectopic fat deposition explored in this study may help establish a consensus on the normal values of RSF volume and FF for the Chinese population. This will facilitate the identification of clinicopathological changes and aid in the investigation of whether RSF volume and FF can serve as early biomarkers for metabolic diseases and renal dysfunction in future studies. |
| first_indexed | 2024-03-12T16:10:50Z |
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| id | doaj.art-c9d4df96c89b4a28897c0056aafbff64 |
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| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T16:10:50Z |
| publishDate | 2023-08-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-c9d4df96c89b4a28897c0056aafbff642023-08-09T13:46:38ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-08-011410.3389/fendo.2023.11877811187781Quantification of the renal sinus fat and exploration of its relationship with ectopic fat deposition in normal subjects using MRI fat fraction mappingQin-He Zhang0Li-Hua Chen1Qi An2Peng Pi3Yi-Fan Dong4Ying Zhao5Nan Wang6Xin Fang7Ren-Wang Pu8Qing-Wei Song9Liang-Jie Lin10Jing-Hong Liu11Ai-Lian Liu12Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Medical Imaging, Dalian Medical University, Dalian, ChinaDepartment of Medical Imaging, Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaClinical & Technical Solutions, Philips Healthcare, Beijing, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaPurposeTo determine the renal sinus fat (RSF) volume and fat fraction (FF) in normal Chinese subjects using MRI fat fraction mapping and to explore their associations with age, gender, body mass index (BMI) and ectopic fat deposition.MethodsA total of 126 subjects were included in the analysis. RSF volume and FF, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area, and hepatic and pancreatic FFs were measured for each subject. The comparisons in gender were determined using two-tailed t-tests or the nonparametric Mann-Whitney U-test for normally or non-normally distributed data for continuous variables and the chi-square test for categorical variables. Comparisons of RFS volume and FF between right and left kidneys were determined using paired sample t-tests. Multivariable logistic models were performed to confirm whether RSF differences between men and women are independent of VAT or SAT area. When parameters were normally distributed, the Pearson correlation coefficient was used; otherwise, the Spearman correlation coefficient was applied.ResultsThe RSF volumes (cm3) of both kidneys in men (26.86 ± 8.81 for right and 31.62 ± 10.32 for left kidneys) were significantly bigger than those of women (21.47 ± 6.90 for right and 26.03 ± 8.55 for left kidneys) (P < 0.05). The RSF FFs (%) of both kidneys in men (28.33 ± 6.73 for right and 31.21 ± 6.29 for left kidneys) were significantly higher than those of the women (23.82 ± 7.74 for right and 27.92 ± 8.15 for left kidneys) (P < 0.05). The RSF differences between men and women are independent of SAT area and dependent of VAT area (except for right RSF volume). In addition, the RSF volumes and FFs in both kidneys in the overall subjects show significant correlations with age, BMI, VAT area, hepatic fat fraction and pancreatic fat fraction (P < 0.05). However, the patterns of these correlations varied by gender. The RSF volume and FF of left kidney were significantly larger than those of the right kidney (P < 0.05).ConclusionThe association between renal sinus fat and ectopic fat deposition explored in this study may help establish a consensus on the normal values of RSF volume and FF for the Chinese population. This will facilitate the identification of clinicopathological changes and aid in the investigation of whether RSF volume and FF can serve as early biomarkers for metabolic diseases and renal dysfunction in future studies.https://www.frontiersin.org/articles/10.3389/fendo.2023.1187781/fullrenal sinus fatmagnetic resonance imagingectopic fat depositionobesityfat quantification |
| spellingShingle | Qin-He Zhang Li-Hua Chen Qi An Peng Pi Yi-Fan Dong Ying Zhao Nan Wang Xin Fang Ren-Wang Pu Qing-Wei Song Liang-Jie Lin Jing-Hong Liu Ai-Lian Liu Quantification of the renal sinus fat and exploration of its relationship with ectopic fat deposition in normal subjects using MRI fat fraction mapping Frontiers in Endocrinology renal sinus fat magnetic resonance imaging ectopic fat deposition obesity fat quantification |
| title | Quantification of the renal sinus fat and exploration of its relationship with ectopic fat deposition in normal subjects using MRI fat fraction mapping |
| title_full | Quantification of the renal sinus fat and exploration of its relationship with ectopic fat deposition in normal subjects using MRI fat fraction mapping |
| title_fullStr | Quantification of the renal sinus fat and exploration of its relationship with ectopic fat deposition in normal subjects using MRI fat fraction mapping |
| title_full_unstemmed | Quantification of the renal sinus fat and exploration of its relationship with ectopic fat deposition in normal subjects using MRI fat fraction mapping |
| title_short | Quantification of the renal sinus fat and exploration of its relationship with ectopic fat deposition in normal subjects using MRI fat fraction mapping |
| title_sort | quantification of the renal sinus fat and exploration of its relationship with ectopic fat deposition in normal subjects using mri fat fraction mapping |
| topic | renal sinus fat magnetic resonance imaging ectopic fat deposition obesity fat quantification |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1187781/full |
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