HectH9 hijacks glucose metabolism to fuel tumor growth
Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-09-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1644599 |
| _version_ | 1827809367918903296 |
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| author | Hong-Jen Lee Jiabei He Chia-Hsin Chan |
| author_facet | Hong-Jen Lee Jiabei He Chia-Hsin Chan |
| author_sort | Hong-Jen Lee |
| collection | DOAJ |
| description | Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH9 is a new strategy to tackle metabolism-addicted tumors. |
| first_indexed | 2024-03-11T22:41:11Z |
| format | Article |
| id | doaj.art-c9d61ab415f44592a6666405a41b3488 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:11Z |
| publishDate | 2019-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-c9d61ab415f44592a6666405a41b34882023-09-22T09:11:01ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-09-016510.1080/23723556.2019.16445991644599HectH9 hijacks glucose metabolism to fuel tumor growthHong-Jen Lee0Jiabei He1Chia-Hsin Chan2Stony Brook UniversityStony Brook UniversityStony Brook UniversityOur study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH9 is a new strategy to tackle metabolism-addicted tumors.http://dx.doi.org/10.1080/23723556.2019.1644599cancer metabolismubiquitinationhexokinasehecth9 |
| spellingShingle | Hong-Jen Lee Jiabei He Chia-Hsin Chan HectH9 hijacks glucose metabolism to fuel tumor growth Molecular & Cellular Oncology cancer metabolism ubiquitination hexokinase hecth9 |
| title | HectH9 hijacks glucose metabolism to fuel tumor growth |
| title_full | HectH9 hijacks glucose metabolism to fuel tumor growth |
| title_fullStr | HectH9 hijacks glucose metabolism to fuel tumor growth |
| title_full_unstemmed | HectH9 hijacks glucose metabolism to fuel tumor growth |
| title_short | HectH9 hijacks glucose metabolism to fuel tumor growth |
| title_sort | hecth9 hijacks glucose metabolism to fuel tumor growth |
| topic | cancer metabolism ubiquitination hexokinase hecth9 |
| url | http://dx.doi.org/10.1080/23723556.2019.1644599 |
| work_keys_str_mv | AT hongjenlee hecth9hijacksglucosemetabolismtofueltumorgrowth AT jiabeihe hecth9hijacksglucosemetabolismtofueltumorgrowth AT chiahsinchan hecth9hijacksglucosemetabolismtofueltumorgrowth |