HectH9 hijacks glucose metabolism to fuel tumor growth

HectH9 hijacks glucose metabolism to fuel tumor growth

Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH...

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Bibliographic Details
Main Authors:	Hong-Jen Lee, Jiabei He, Chia-Hsin Chan
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-09-01
Series:	Molecular & Cellular Oncology
Subjects:	cancer metabolism ubiquitination hexokinase hecth9
Online Access:	http://dx.doi.org/10.1080/23723556.2019.1644599

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