Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease

Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease

Abstract Pompe disease is a metabolic myopathy due to acid alpha‐glucosidase deficiency. In addition to glycogen storage, secondary dysregulation of cellular functions, such as autophagy and oxidative stress, contributes to the disease pathophysiology. We have tested whether oxidative stress impacts...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Antonietta Tarallo, Carla Damiano, Sandra Strollo, Nadia Minopoli, Alessia Indrieri, Elena Polishchuk, Francesca Zappa, Edoardo Nusco, Simona Fecarotta, Caterina Porto, Marcella Coletta, Roberta Iacono, Marco Moracci, Roman Polishchuk, Diego Luis Medina, Paola Imbimbo, Daria Maria Monti, Maria Antonietta De Matteis, Giancarlo Parenti
التنسيق: مقال
اللغة:English
منشور في: Springer Nature 2021-10-01
سلاسل:EMBO Molecular Medicine
الموضوعات:
alpha‐glucosidase
enzyme replacement therapy
N‐acetylcysteine
oxidative stress
Pompe disease
الوصول للمادة أونلاين:https://doi.org/10.15252/emmm.202114434

الانترنت

https://doi.org/10.15252/emmm.202114434

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