Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep
Cholecystokinin (CCK) affects the intestinal motility but in ruminants the question has not been entirely explored. The aim of this study was to examine the precise effects of CCK-octapeptide (CCK-OP)and its amphibian analogue, cerulein, on duodenal motor activity in unfasted rams in the course of c...
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2010-08-01
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| Series: | Czech Journal of Animal Science |
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| Online Access: | https://cjas.agriculturejournals.cz/artkey/cjs-201008-0003_effects-of-cholecystokinin-octapeptide-and-cerulein-on-small-intestinal-motility-in-sheep.php |
| _version_ | 1797899294844387328 |
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| author | K.W. Romański |
| author_facet | K.W. Romański |
| author_sort | K.W. Romański |
| collection | DOAJ |
| description | Cholecystokinin (CCK) affects the intestinal motility but in ruminants the question has not been entirely explored. The aim of this study was to examine the precise effects of CCK-octapeptide (CCK-OP)and its amphibian analogue, cerulein, on duodenal motor activity in unfasted rams in the course of chronic experiments. Five rams underwent the implantation of a strain gauge force transducer to the duodenal wall, and - additionally - the bipolar platinum electrodes to the duodenal bulb, distal duodenum, near the strain gauge force transducer, and proximal jejunum. During continuous motor recordings, 0.15M NaCl or CCK peptides were administrated intravenously. Injections of CCK-OP at doses of 20 (over 30 s), 200 (over 30 or 60 s), and 2 000 (over 30, 60, or 120 s) ng/kg of body weight and injections of cerulein at doses of 1, 10, or 100 ng/kg (given over the same periods) were each administered in the course of duodenal phase 1, 2a, or 2b of the migrating motor complex (MMC), i.e. 5 min after the onset of each phase. Injections of the smallest doses of CCK peptides exerted a slight and mostly insignificant effect on the duodenal areas under contraction (AUC). In the duodenum, the moderate doses of the hormones evoked short stimulatory effects followed by longer inhibitory biphasic effects on AUC. These effects were inversely related to the duration of the hormone injection. It is concluded that CCK evokes stimulatory and inhibitory (biphasic) physiological effects on duodenal motility in sheep. |
| first_indexed | 2024-04-10T08:27:40Z |
| format | Article |
| id | doaj.art-c9d7710d0bb14941a2acd1ca6212aff6 |
| institution | Directory Open Access Journal |
| issn | 1212-1819 1805-9309 |
| language | English |
| last_indexed | 2024-04-10T08:27:40Z |
| publishDate | 2010-08-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Czech Journal of Animal Science |
| spelling | doaj.art-c9d7710d0bb14941a2acd1ca6212aff62023-02-23T03:32:48ZengCzech Academy of Agricultural SciencesCzech Journal of Animal Science1212-18191805-93092010-08-0155832132910.17221/1692-CJAScjs-201008-0003Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheepK.W. Romański0Department of Biostructure and Animal Physiology, Veterinary School, Wrocław University of Environmental and Life Sciences, Wrocław, PolandCholecystokinin (CCK) affects the intestinal motility but in ruminants the question has not been entirely explored. The aim of this study was to examine the precise effects of CCK-octapeptide (CCK-OP)and its amphibian analogue, cerulein, on duodenal motor activity in unfasted rams in the course of chronic experiments. Five rams underwent the implantation of a strain gauge force transducer to the duodenal wall, and - additionally - the bipolar platinum electrodes to the duodenal bulb, distal duodenum, near the strain gauge force transducer, and proximal jejunum. During continuous motor recordings, 0.15M NaCl or CCK peptides were administrated intravenously. Injections of CCK-OP at doses of 20 (over 30 s), 200 (over 30 or 60 s), and 2 000 (over 30, 60, or 120 s) ng/kg of body weight and injections of cerulein at doses of 1, 10, or 100 ng/kg (given over the same periods) were each administered in the course of duodenal phase 1, 2a, or 2b of the migrating motor complex (MMC), i.e. 5 min after the onset of each phase. Injections of the smallest doses of CCK peptides exerted a slight and mostly insignificant effect on the duodenal areas under contraction (AUC). In the duodenum, the moderate doses of the hormones evoked short stimulatory effects followed by longer inhibitory biphasic effects on AUC. These effects were inversely related to the duration of the hormone injection. It is concluded that CCK evokes stimulatory and inhibitory (biphasic) physiological effects on duodenal motility in sheep.https://cjas.agriculturejournals.cz/artkey/cjs-201008-0003_effects-of-cholecystokinin-octapeptide-and-cerulein-on-small-intestinal-motility-in-sheep.phpsheepduodenummotor activitycholecystokinin octapeptideceruleinmigrating motor complex |
| spellingShingle | K.W. Romański Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep Czech Journal of Animal Science sheep duodenum motor activity cholecystokinin octapeptide cerulein migrating motor complex |
| title | Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep |
| title_full | Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep |
| title_fullStr | Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep |
| title_full_unstemmed | Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep |
| title_short | Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep |
| title_sort | effects of cholecystokinin octapeptide and cerulein on small intestinal motility in sheep |
| topic | sheep duodenum motor activity cholecystokinin octapeptide cerulein migrating motor complex |
| url | https://cjas.agriculturejournals.cz/artkey/cjs-201008-0003_effects-of-cholecystokinin-octapeptide-and-cerulein-on-small-intestinal-motility-in-sheep.php |
| work_keys_str_mv | AT kwromanski effectsofcholecystokininoctapeptideandceruleinonsmallintestinalmotilityinsheep |