Transfusion of stored autologous blood in patients with low-grade pseudomyxoma peritonei: A retrospective analysis of its safety and outcome
BackgroundPseudomyxoma peritonei is a rare disease that presents as a malignant tumor on the peritoneal surface. Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is the standard treatment for this disease and frequently requires a red blood cell transfusion. However, due...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1022426/full |
| _version_ | 1811196296733655040 |
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| author | Xiaoyun Gao Liduo Kou Hang Guan Hua Tian Junhui Jia Yu Bai Wei Bai Yanhui Di Ruiqing Ma Xinhua Wang |
| author_facet | Xiaoyun Gao Liduo Kou Hang Guan Hua Tian Junhui Jia Yu Bai Wei Bai Yanhui Di Ruiqing Ma Xinhua Wang |
| author_sort | Xiaoyun Gao |
| collection | DOAJ |
| description | BackgroundPseudomyxoma peritonei is a rare disease that presents as a malignant tumor on the peritoneal surface. Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is the standard treatment for this disease and frequently requires a red blood cell transfusion. However, due to the limited collection and supply of allogeneic blood, surgical treatment may be delayed due to inadequate preparation of allogeneic blood in the course of clinical treatment. This study aimed to evaluate the safety and efficacy of transfusion of stored autologous blood in patients with low-grade pseudomyxoma peritonei.MethodsPseudomyxoma peritonei patients who received cytoreductive surgery combined with heat-infused peritoneal chemotherapy were divided into two groups: transfusion of allogeneic blood and transfusion of stored autologous blood. A comparison of the differences in multiple factors between the two groups was performed, including tumor recurrence, survival time, hemoglobin and hematocrit levels, coagulation function (prothrombin time, activated partial thromboplastin time, and fibrinogen), total hospital stay duration, and incidence of serious adverse events after surgery.ResultsPropensity scores matching analysis yielded 34 patients with allogeneic blood transfusion and 34 patients with stored autologous blood transfusion. Comparison analysis did not show statistical differences in several factors, including age, tumor grade, tumor recurrence rate after surgery, etc., between the two groups. The cytoreductive degree was considered an independent risk factor for tumor recurrence. The pseudomyxoma peritonei patients in the autologous transfusion group had a higher 5-year survival rate and a longer survival time. Moreover, transfusion of stored autologous blood did not increase the rate of tumor recurrence, or the total hospital stay duration after surgery, the hemoglobin level and coagulation function were well stabilized within 24 h after surgery, and there was a low incidence of serious adverse events.ConclusionThe clinical application of transfusion of stored autologous blood in pseudomyxoma peritonei patients is safe and effective. |
| first_indexed | 2024-04-12T00:57:18Z |
| format | Article |
| id | doaj.art-c9d9ea47272f438cb106cb2dea536f33 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T00:57:18Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c9d9ea47272f438cb106cb2dea536f332022-12-22T03:54:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.10224261022426Transfusion of stored autologous blood in patients with low-grade pseudomyxoma peritonei: A retrospective analysis of its safety and outcomeXiaoyun Gao0Liduo Kou1Hang Guan2Hua Tian3Junhui Jia4Yu Bai5Wei Bai6Yanhui Di7Ruiqing Ma8Xinhua Wang9Department of Blood Transfusion, Aerospace Center Hospital, Beijing, ChinaDepartment of Blood Transfusion, Aerospace Center Hospital, Beijing, ChinaDepartment of Blood Transfusion, Aerospace Center Hospital, Beijing, ChinaDepartment of Blood Transfusion, Aerospace Center Hospital, Beijing, ChinaDepartment of Blood Transfusion, Aerospace Center Hospital, Beijing, ChinaDepartment of Blood Transfusion, Aerospace Center Hospital, Beijing, ChinaDepartment of Blood Transfusion, Aerospace Center Hospital, Beijing, ChinaDepartment of Blood Transfusion, Aerospace Center Hospital, Beijing, ChinaDepartment of Myxoma, Aerospace Center Hospital, Beijing, ChinaDepartment of Blood Transfusion, Aerospace Center Hospital, Beijing, ChinaBackgroundPseudomyxoma peritonei is a rare disease that presents as a malignant tumor on the peritoneal surface. Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is the standard treatment for this disease and frequently requires a red blood cell transfusion. However, due to the limited collection and supply of allogeneic blood, surgical treatment may be delayed due to inadequate preparation of allogeneic blood in the course of clinical treatment. This study aimed to evaluate the safety and efficacy of transfusion of stored autologous blood in patients with low-grade pseudomyxoma peritonei.MethodsPseudomyxoma peritonei patients who received cytoreductive surgery combined with heat-infused peritoneal chemotherapy were divided into two groups: transfusion of allogeneic blood and transfusion of stored autologous blood. A comparison of the differences in multiple factors between the two groups was performed, including tumor recurrence, survival time, hemoglobin and hematocrit levels, coagulation function (prothrombin time, activated partial thromboplastin time, and fibrinogen), total hospital stay duration, and incidence of serious adverse events after surgery.ResultsPropensity scores matching analysis yielded 34 patients with allogeneic blood transfusion and 34 patients with stored autologous blood transfusion. Comparison analysis did not show statistical differences in several factors, including age, tumor grade, tumor recurrence rate after surgery, etc., between the two groups. The cytoreductive degree was considered an independent risk factor for tumor recurrence. The pseudomyxoma peritonei patients in the autologous transfusion group had a higher 5-year survival rate and a longer survival time. Moreover, transfusion of stored autologous blood did not increase the rate of tumor recurrence, or the total hospital stay duration after surgery, the hemoglobin level and coagulation function were well stabilized within 24 h after surgery, and there was a low incidence of serious adverse events.ConclusionThe clinical application of transfusion of stored autologous blood in pseudomyxoma peritonei patients is safe and effective.https://www.frontiersin.org/articles/10.3389/fonc.2022.1022426/fullpseudomyxoma peritoneistored autologous blood transfusionrecurrence ratepropensity score matchingcoagulation function |
| spellingShingle | Xiaoyun Gao Liduo Kou Hang Guan Hua Tian Junhui Jia Yu Bai Wei Bai Yanhui Di Ruiqing Ma Xinhua Wang Transfusion of stored autologous blood in patients with low-grade pseudomyxoma peritonei: A retrospective analysis of its safety and outcome Frontiers in Oncology pseudomyxoma peritonei stored autologous blood transfusion recurrence rate propensity score matching coagulation function |
| title | Transfusion of stored autologous blood in patients with low-grade pseudomyxoma peritonei: A retrospective analysis of its safety and outcome |
| title_full | Transfusion of stored autologous blood in patients with low-grade pseudomyxoma peritonei: A retrospective analysis of its safety and outcome |
| title_fullStr | Transfusion of stored autologous blood in patients with low-grade pseudomyxoma peritonei: A retrospective analysis of its safety and outcome |
| title_full_unstemmed | Transfusion of stored autologous blood in patients with low-grade pseudomyxoma peritonei: A retrospective analysis of its safety and outcome |
| title_short | Transfusion of stored autologous blood in patients with low-grade pseudomyxoma peritonei: A retrospective analysis of its safety and outcome |
| title_sort | transfusion of stored autologous blood in patients with low grade pseudomyxoma peritonei a retrospective analysis of its safety and outcome |
| topic | pseudomyxoma peritonei stored autologous blood transfusion recurrence rate propensity score matching coagulation function |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1022426/full |
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