Acidic Fibroblast Growth Factor in Spinal Cord Injury
Spinal cord injury (SCI), with an incidence rate of 246 per million person-years among adults in Taiwan, remains a devastating disease in the modern day. Elderly men with lower socioeconomic status have an even higher risk for SCI. Despite advances made in medicine and technology to date, there are...
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| Format: | Article |
| Language: | English |
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Korean Spinal Neurosurgery Society
2019-12-01
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| Series: | Neurospine |
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| Online Access: | http://www.e-neurospine.org/upload/pdf/ns-1836216-108.pdf |
| _version_ | 1797334163389415424 |
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| author | Chin-Chu Ko Tsung-Hsi Tu Jau-Ching Wu Wen-Cheng Huang Henrich Cheng |
| author_facet | Chin-Chu Ko Tsung-Hsi Tu Jau-Ching Wu Wen-Cheng Huang Henrich Cheng |
| author_sort | Chin-Chu Ko |
| collection | DOAJ |
| description | Spinal cord injury (SCI), with an incidence rate of 246 per million person-years among adults in Taiwan, remains a devastating disease in the modern day. Elderly men with lower socioeconomic status have an even higher risk for SCI. Despite advances made in medicine and technology to date, there are few effective treatments for SCI due to limitations in the regenerative capacity of the adult central nervous system. Experiments and clinical trials have explored neuro-regeneration in human SCI, encompassing cell- and molecule-based therapies. Furthermore, strategies have aimed at restoring connections, including autologous peripheral nerve grafts and biomaterial scaffolds that theoretically promote axonal growth. Most molecule-based therapies target the modulation of inhibitory molecules to promote axonal growth, degrade glial scarring obstacles, and stimulate intrinsic regenerative capacity. Among them, acidic fibroblast growth factor (aFGF) has been investigated for nerve repair; it is mitogenic and pluripotent in nature and could enhance axonal growth and mitigate glial scarring. For more than 2 decades, the authors have conducted multiple trials, including human and animal experiments, using aFGF to repair nerve injuries, including central and peripheral nerves. In these trials, aFGF has shown promise for neural regeneration, and in the future, more trials and applications should investigate aFGF as a neurotrophic factor. Focusing on aFGF, the current review aimed to summarize the historical evolution of the utilization of aFGF in SCI and nerve injuries, to present applications and trials, to summarize briefly its possible mechanisms, and to provide future perspectives. |
| first_indexed | 2024-03-08T08:15:47Z |
| format | Article |
| id | doaj.art-c9db489fba394ed393bcd6fb4f599030 |
| institution | Directory Open Access Journal |
| issn | 2586-6583 2586-6591 |
| language | English |
| last_indexed | 2024-03-08T08:15:47Z |
| publishDate | 2019-12-01 |
| publisher | Korean Spinal Neurosurgery Society |
| record_format | Article |
| series | Neurospine |
| spelling | doaj.art-c9db489fba394ed393bcd6fb4f5990302024-02-02T07:28:55ZengKorean Spinal Neurosurgery SocietyNeurospine2586-65832586-65912019-12-0116472873810.14245/ns.1836216.108842Acidic Fibroblast Growth Factor in Spinal Cord InjuryChin-Chu Ko0Tsung-Hsi Tu1Jau-Ching Wu2Wen-Cheng Huang3Henrich Cheng4 Jhong Jheng Spine & Orthopedic Hospital, Kaohsiung, Taiwan School of Medicine, National Yang-Ming University, Taipei, Taiwan Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan School of Medicine, National Yang-Ming University, Taipei, Taiwan Institute of Pharmacology, National Yang-Ming University, Taipei, TaiwanSpinal cord injury (SCI), with an incidence rate of 246 per million person-years among adults in Taiwan, remains a devastating disease in the modern day. Elderly men with lower socioeconomic status have an even higher risk for SCI. Despite advances made in medicine and technology to date, there are few effective treatments for SCI due to limitations in the regenerative capacity of the adult central nervous system. Experiments and clinical trials have explored neuro-regeneration in human SCI, encompassing cell- and molecule-based therapies. Furthermore, strategies have aimed at restoring connections, including autologous peripheral nerve grafts and biomaterial scaffolds that theoretically promote axonal growth. Most molecule-based therapies target the modulation of inhibitory molecules to promote axonal growth, degrade glial scarring obstacles, and stimulate intrinsic regenerative capacity. Among them, acidic fibroblast growth factor (aFGF) has been investigated for nerve repair; it is mitogenic and pluripotent in nature and could enhance axonal growth and mitigate glial scarring. For more than 2 decades, the authors have conducted multiple trials, including human and animal experiments, using aFGF to repair nerve injuries, including central and peripheral nerves. In these trials, aFGF has shown promise for neural regeneration, and in the future, more trials and applications should investigate aFGF as a neurotrophic factor. Focusing on aFGF, the current review aimed to summarize the historical evolution of the utilization of aFGF in SCI and nerve injuries, to present applications and trials, to summarize briefly its possible mechanisms, and to provide future perspectives.http://www.e-neurospine.org/upload/pdf/ns-1836216-108.pdfacidic fibroblast growth factorspinal cord injuryregeneration |
| spellingShingle | Chin-Chu Ko Tsung-Hsi Tu Jau-Ching Wu Wen-Cheng Huang Henrich Cheng Acidic Fibroblast Growth Factor in Spinal Cord Injury Neurospine acidic fibroblast growth factor spinal cord injury regeneration |
| title | Acidic Fibroblast Growth Factor in Spinal Cord Injury |
| title_full | Acidic Fibroblast Growth Factor in Spinal Cord Injury |
| title_fullStr | Acidic Fibroblast Growth Factor in Spinal Cord Injury |
| title_full_unstemmed | Acidic Fibroblast Growth Factor in Spinal Cord Injury |
| title_short | Acidic Fibroblast Growth Factor in Spinal Cord Injury |
| title_sort | acidic fibroblast growth factor in spinal cord injury |
| topic | acidic fibroblast growth factor spinal cord injury regeneration |
| url | http://www.e-neurospine.org/upload/pdf/ns-1836216-108.pdf |
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