Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes
Embryonal Rhabdomyosarcoma (ERMS) and Undifferentiated Pleomorphic Sarcoma (UPS) are distinct sarcoma subtypes. Here we investigate the relevance of the satellite cell (SC) niche in sarcoma development by using Hepatocyte Growth Factor (HGF) to perturb the niche microenvironment. In a Pax7 wild type...
Main Authors: | Deborah Morena, Nicola Maestro, Francesca Bersani, Paolo Emanuele Forni, Marcello Francesco Lingua, Valentina Foglizzo, Petar Šćepanović, Silvia Miretti, Alessandro Morotti, Jack F Shern, Javed Khan, Ugo Ala, Paolo Provero, Valentina Sala, Tiziana Crepaldi, Patrizia Gasparini, Michela Casanova, Andrea Ferrari, Gabriella Sozzi, Roberto Chiarle, Carola Ponzetto, Riccardo Taulli |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/12116 |
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