Treatment Outcomes of Tuberculosis at Asella Teaching Hospital, Ethiopia: Ten Years’ Retrospective Aggregated Data
BackgroundDirectly Observed Treatment Short-course (DOTS) has been one of the major strategies to combat the epidemic of tuberculosis (TB) globally. This study aimed to evaluate TB treatment outcomes between September 2004 and July 2014 under the DOTS program at one of the largest public hospitals i...
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| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fmed.2018.00038/full |
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| author | Ketema Tafess Ketema Tafess Teresa Kisi Beyen Adugna Abera Geremew Tasew Shimelis Mekit Solomon Sisay Legesse Tadesse Gilman K. H. Siu |
| author_facet | Ketema Tafess Ketema Tafess Teresa Kisi Beyen Adugna Abera Geremew Tasew Shimelis Mekit Solomon Sisay Legesse Tadesse Gilman K. H. Siu |
| author_sort | Ketema Tafess |
| collection | DOAJ |
| description | BackgroundDirectly Observed Treatment Short-course (DOTS) has been one of the major strategies to combat the epidemic of tuberculosis (TB) globally. This study aimed to evaluate TB treatment outcomes between September 2004 and July 2014 under the DOTS program at one of the largest public hospitals in Ethiopia.MethodsA retrospective data of TB patients registered at Asella Teaching Hospital between September 2004 and July 2014 were obtained from hospital registry. Treatment outcomes and types of TB cases were categorized according to the national TB control program guideline. Binomial and multinomial logistic regression models were used to analyze the association between treatment outcomes and potential predictor variables.ResultsA total of 1,755 TB patients’ records were included in the study. Of these, 945 (53.8%) were male, 480 (27.4%) smear-positive TB, 287 (16.4%) HIV positive, and 1,549 (88.3%) new cases. Among 480 smear-positive pulmonary TB cases, 377 (78.5%) patients were cured, 21 (4.40) completed the treatment, 35 (7.3%) transferred out, 19 (4.0%) died, 24 (5.0%) defaulted, and 4 (0.8%) failure. Overall, 398 (82.9%) smear-positive pulmonary TB patients were successfully treated. For smear-negative TB (n = 641) and extrapulmonary TB cases (n = 634), 1,036 (81.3%) completed the treatment and demonstrated favorable response. Taking all TB types into account, 1,434 (81.7%) were considered as successfully treated. In the multivariate binary logistic model, patients in older age group (AOR = 0.386, 95% CI: 0.250–0.596) and retreatment cases (AOR = 0.422, 95% CI: 0.226–0.790) were less likely to be successfully treated compared to younger and new cases, respectively. In multinomial logistic regression, age increment by 1 year increased the risk of death and default of TB patients by 0.05 (adjusted β = 0.05; 95% CI: 0.03, 0.06) and 0.02 (adjusted β = 0.02; 95% CI: 0.01, 0.04). The odds of TB patients who died during treatment were higher among HIV-infected TB patients (adjusted β = 2.65; 95% CI: 1.28, 5.50).ConclusionThe treatment success rate of TB patients was low as compared to the national target. TB control needs to be strengthened for the enhancement of treatment outcome. |
| first_indexed | 2024-12-10T15:48:59Z |
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| id | doaj.art-c9dbe053e14145b3a52f0f968f6c146a |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-10T15:48:59Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-c9dbe053e14145b3a52f0f968f6c146a2022-12-22T01:42:52ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2018-02-01510.3389/fmed.2018.00038314007Treatment Outcomes of Tuberculosis at Asella Teaching Hospital, Ethiopia: Ten Years’ Retrospective Aggregated DataKetema Tafess0Ketema Tafess1Teresa Kisi Beyen2Adugna Abera3Geremew Tasew4Shimelis Mekit5Solomon Sisay6Legesse Tadesse7Gilman K. H. Siu8Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong KongDepartment of Medical Laboratory, College of Health Sciences, Arsi University, Asella, EthiopiaDepartment of Public Health, College of Health Sciences, Arsi University, Asella, EthiopiaLeishmaniasis Research Laboratory, Ethiopia Public Health Institute, Addis Ababa, EthiopiaLeishmaniasis Research Laboratory, Ethiopia Public Health Institute, Addis Ababa, EthiopiaDepartment of Pharmacy, College of Health Sciences, Arsi University, Asella, EthiopiaDepartment of Medical, GLRA-Ethiopia, Addis Ababa, EthiopiaDepartment of Public Health, College of Health Sciences, Arsi University, Asella, EthiopiaDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong KongBackgroundDirectly Observed Treatment Short-course (DOTS) has been one of the major strategies to combat the epidemic of tuberculosis (TB) globally. This study aimed to evaluate TB treatment outcomes between September 2004 and July 2014 under the DOTS program at one of the largest public hospitals in Ethiopia.MethodsA retrospective data of TB patients registered at Asella Teaching Hospital between September 2004 and July 2014 were obtained from hospital registry. Treatment outcomes and types of TB cases were categorized according to the national TB control program guideline. Binomial and multinomial logistic regression models were used to analyze the association between treatment outcomes and potential predictor variables.ResultsA total of 1,755 TB patients’ records were included in the study. Of these, 945 (53.8%) were male, 480 (27.4%) smear-positive TB, 287 (16.4%) HIV positive, and 1,549 (88.3%) new cases. Among 480 smear-positive pulmonary TB cases, 377 (78.5%) patients were cured, 21 (4.40) completed the treatment, 35 (7.3%) transferred out, 19 (4.0%) died, 24 (5.0%) defaulted, and 4 (0.8%) failure. Overall, 398 (82.9%) smear-positive pulmonary TB patients were successfully treated. For smear-negative TB (n = 641) and extrapulmonary TB cases (n = 634), 1,036 (81.3%) completed the treatment and demonstrated favorable response. Taking all TB types into account, 1,434 (81.7%) were considered as successfully treated. In the multivariate binary logistic model, patients in older age group (AOR = 0.386, 95% CI: 0.250–0.596) and retreatment cases (AOR = 0.422, 95% CI: 0.226–0.790) were less likely to be successfully treated compared to younger and new cases, respectively. In multinomial logistic regression, age increment by 1 year increased the risk of death and default of TB patients by 0.05 (adjusted β = 0.05; 95% CI: 0.03, 0.06) and 0.02 (adjusted β = 0.02; 95% CI: 0.01, 0.04). The odds of TB patients who died during treatment were higher among HIV-infected TB patients (adjusted β = 2.65; 95% CI: 1.28, 5.50).ConclusionThe treatment success rate of TB patients was low as compared to the national target. TB control needs to be strengthened for the enhancement of treatment outcome.http://journal.frontiersin.org/article/10.3389/fmed.2018.00038/fulltuberculosisAsellaoutcomessmear-positive pulmonary tuberculosissmear-negative pulmonary tuberculosis |
| spellingShingle | Ketema Tafess Ketema Tafess Teresa Kisi Beyen Adugna Abera Geremew Tasew Shimelis Mekit Solomon Sisay Legesse Tadesse Gilman K. H. Siu Treatment Outcomes of Tuberculosis at Asella Teaching Hospital, Ethiopia: Ten Years’ Retrospective Aggregated Data Frontiers in Medicine tuberculosis Asella outcomes smear-positive pulmonary tuberculosis smear-negative pulmonary tuberculosis |
| title | Treatment Outcomes of Tuberculosis at Asella Teaching Hospital, Ethiopia: Ten Years’ Retrospective Aggregated Data |
| title_full | Treatment Outcomes of Tuberculosis at Asella Teaching Hospital, Ethiopia: Ten Years’ Retrospective Aggregated Data |
| title_fullStr | Treatment Outcomes of Tuberculosis at Asella Teaching Hospital, Ethiopia: Ten Years’ Retrospective Aggregated Data |
| title_full_unstemmed | Treatment Outcomes of Tuberculosis at Asella Teaching Hospital, Ethiopia: Ten Years’ Retrospective Aggregated Data |
| title_short | Treatment Outcomes of Tuberculosis at Asella Teaching Hospital, Ethiopia: Ten Years’ Retrospective Aggregated Data |
| title_sort | treatment outcomes of tuberculosis at asella teaching hospital ethiopia ten years retrospective aggregated data |
| topic | tuberculosis Asella outcomes smear-positive pulmonary tuberculosis smear-negative pulmonary tuberculosis |
| url | http://journal.frontiersin.org/article/10.3389/fmed.2018.00038/full |
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