Effect of clonidine and magnesium sulphate on anaesthetic consumption, haemodynamics and postoperative recovery: A comparative study
This randomised, placebo-controlled, double-blind study was designed to assess the effect of intravenous clonidine and magnesium sulphate on intraoperative haemodynamics, anaesthetic consumption and postoperative recovery. Seventy five patients undergoing elective upper limb orthopaedic surgery were...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Indian Journal of Anaesthesia |
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| Online Access: | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2010;volume=54;issue=2;spage=137;epage=141;aulast=Ray |
| _version_ | 1819055230697865216 |
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| author | Manjushree Ray Dhurjoti Prosad Bhattacharjee Bimal Hajra Rita Pal Nilay Chatterjee |
| author_facet | Manjushree Ray Dhurjoti Prosad Bhattacharjee Bimal Hajra Rita Pal Nilay Chatterjee |
| author_sort | Manjushree Ray |
| collection | DOAJ |
| description | This randomised, placebo-controlled, double-blind study was designed to assess the effect of intravenous clonidine and magnesium sulphate on intraoperative haemodynamics, anaesthetic consumption and postoperative recovery. Seventy five patients undergoing elective upper limb orthopaedic surgery were randomised into three groups. Group C received clonidine 3 μg/kg as a bolus before induction and 1μg/kg/hour by infusion intraopertively. Group M received magnesium sulphate 30 mg/kg as a bolus before induction and 10 mg/kg/hour by infusion. Group P received same volume of isotonic saline. Anaesthesia was induced and maintained with fentanyl citrate and propofol. Muscular relaxation was achieved by vecuronium bromide. Induction time, recovery time and consumption of propofol as well as fentanyl citrate were recorded. Induction of anaesthesia was rapid with both clonidine and magnesium sulphate. Time of bispectral index (BIS) to reach 60 was significantly lower in Group C and Group M (P < 0.0001). Requirements of propofol and fentanyl were significantly less in Group C and Group M (P < 0.001). Postoperative recovery was slower in Group M compared with other two groups (P < 0.001). Perioperative use of both clonidine and magnesium sulphate significantly reduced the consumption of propofol and fentanyl citrate. Magnesium sulphate caused a delayed recovery. |
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| institution | Directory Open Access Journal |
| issn | 0019-5049 |
| language | English |
| last_indexed | 2024-12-21T13:04:13Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Indian Journal of Anaesthesia |
| spelling | doaj.art-c9debdb0e2f14308907aea266d663a8e2022-12-21T19:03:05ZengWolters Kluwer Medknow PublicationsIndian Journal of Anaesthesia0019-50492010-01-0154213714110.4103/0019-5049.63659Effect of clonidine and magnesium sulphate on anaesthetic consumption, haemodynamics and postoperative recovery: A comparative studyManjushree RayDhurjoti Prosad BhattacharjeeBimal HajraRita PalNilay ChatterjeeThis randomised, placebo-controlled, double-blind study was designed to assess the effect of intravenous clonidine and magnesium sulphate on intraoperative haemodynamics, anaesthetic consumption and postoperative recovery. Seventy five patients undergoing elective upper limb orthopaedic surgery were randomised into three groups. Group C received clonidine 3 μg/kg as a bolus before induction and 1μg/kg/hour by infusion intraopertively. Group M received magnesium sulphate 30 mg/kg as a bolus before induction and 10 mg/kg/hour by infusion. Group P received same volume of isotonic saline. Anaesthesia was induced and maintained with fentanyl citrate and propofol. Muscular relaxation was achieved by vecuronium bromide. Induction time, recovery time and consumption of propofol as well as fentanyl citrate were recorded. Induction of anaesthesia was rapid with both clonidine and magnesium sulphate. Time of bispectral index (BIS) to reach 60 was significantly lower in Group C and Group M (P < 0.0001). Requirements of propofol and fentanyl were significantly less in Group C and Group M (P < 0.001). Postoperative recovery was slower in Group M compared with other two groups (P < 0.001). Perioperative use of both clonidine and magnesium sulphate significantly reduced the consumption of propofol and fentanyl citrate. Magnesium sulphate caused a delayed recovery.http://www.ijaweb.org/article.asp?issn=0019-5049;year=2010;volume=54;issue=2;spage=137;epage=141;aulast=RayAnaesthetic consumptionbispectral indexclonidinemagnesium sulphate |
| spellingShingle | Manjushree Ray Dhurjoti Prosad Bhattacharjee Bimal Hajra Rita Pal Nilay Chatterjee Effect of clonidine and magnesium sulphate on anaesthetic consumption, haemodynamics and postoperative recovery: A comparative study Indian Journal of Anaesthesia Anaesthetic consumption bispectral index clonidine magnesium sulphate |
| title | Effect of clonidine and magnesium sulphate on anaesthetic consumption, haemodynamics and postoperative recovery: A comparative study |
| title_full | Effect of clonidine and magnesium sulphate on anaesthetic consumption, haemodynamics and postoperative recovery: A comparative study |
| title_fullStr | Effect of clonidine and magnesium sulphate on anaesthetic consumption, haemodynamics and postoperative recovery: A comparative study |
| title_full_unstemmed | Effect of clonidine and magnesium sulphate on anaesthetic consumption, haemodynamics and postoperative recovery: A comparative study |
| title_short | Effect of clonidine and magnesium sulphate on anaesthetic consumption, haemodynamics and postoperative recovery: A comparative study |
| title_sort | effect of clonidine and magnesium sulphate on anaesthetic consumption haemodynamics and postoperative recovery a comparative study |
| topic | Anaesthetic consumption bispectral index clonidine magnesium sulphate |
| url | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2010;volume=54;issue=2;spage=137;epage=141;aulast=Ray |
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