Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states
Pattern completion, or the ability to retrieve stable neural activity patterns from noisy or partial cues, is a fundamental feature of memory. Theoretical studies indicate that recurrently connected auto-associative or discrete attractor networks can perform this process. Although pattern completion...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-07-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/53125 |
| _version_ | 1818028545751908352 |
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| author | Kevin A Bolding Shivathmihai Nagappan Bao-Xia Han Fan Wang Kevin M Franks |
| author_facet | Kevin A Bolding Shivathmihai Nagappan Bao-Xia Han Fan Wang Kevin M Franks |
| author_sort | Kevin A Bolding |
| collection | DOAJ |
| description | Pattern completion, or the ability to retrieve stable neural activity patterns from noisy or partial cues, is a fundamental feature of memory. Theoretical studies indicate that recurrently connected auto-associative or discrete attractor networks can perform this process. Although pattern completion and attractor dynamics have been observed in various recurrent neural circuits, the role recurrent circuitry plays in implementing these processes remains unclear. In recordings from head-fixed mice, we found that odor responses in olfactory bulb degrade under ketamine/xylazine anesthesia while responses immediately downstream, in piriform cortex, remain robust. Recurrent connections are required to stabilize cortical odor representations across states. Moreover, piriform odor representations exhibit attractor dynamics, both within and across trials, and these are also abolished when recurrent circuitry is eliminated. Here, we present converging evidence that recurrently-connected piriform populations stabilize sensory representations in response to degraded inputs, consistent with an auto-associative function for piriform cortex supported by recurrent circuitry. |
| first_indexed | 2024-12-10T05:05:30Z |
| format | Article |
| id | doaj.art-c9defb6063374addb97285f4879097ec |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T05:05:30Z |
| publishDate | 2020-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-c9defb6063374addb97285f4879097ec2022-12-22T02:01:15ZengeLife Sciences Publications LtdeLife2050-084X2020-07-01910.7554/eLife.53125Recurrent circuitry is required to stabilize piriform cortex odor representations across brain statesKevin A Bolding0https://orcid.org/0000-0002-2271-5280Shivathmihai Nagappan1Bao-Xia Han2Fan Wang3Kevin M Franks4https://orcid.org/0000-0002-6386-9518Department of Neurobiology, Duke University Medical School, Durham, United StatesDepartment of Neurobiology, Duke University Medical School, Durham, United StatesDepartment of Neurobiology, Duke University Medical School, Durham, United StatesDepartment of Neurobiology, Duke University Medical School, Durham, United StatesDepartment of Neurobiology, Duke University Medical School, Durham, United StatesPattern completion, or the ability to retrieve stable neural activity patterns from noisy or partial cues, is a fundamental feature of memory. Theoretical studies indicate that recurrently connected auto-associative or discrete attractor networks can perform this process. Although pattern completion and attractor dynamics have been observed in various recurrent neural circuits, the role recurrent circuitry plays in implementing these processes remains unclear. In recordings from head-fixed mice, we found that odor responses in olfactory bulb degrade under ketamine/xylazine anesthesia while responses immediately downstream, in piriform cortex, remain robust. Recurrent connections are required to stabilize cortical odor representations across states. Moreover, piriform odor representations exhibit attractor dynamics, both within and across trials, and these are also abolished when recurrent circuitry is eliminated. Here, we present converging evidence that recurrently-connected piriform populations stabilize sensory representations in response to degraded inputs, consistent with an auto-associative function for piriform cortex supported by recurrent circuitry.https://elifesciences.org/articles/53125olfactioncortical circuitspattern completion |
| spellingShingle | Kevin A Bolding Shivathmihai Nagappan Bao-Xia Han Fan Wang Kevin M Franks Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states eLife olfaction cortical circuits pattern completion |
| title | Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states |
| title_full | Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states |
| title_fullStr | Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states |
| title_full_unstemmed | Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states |
| title_short | Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states |
| title_sort | recurrent circuitry is required to stabilize piriform cortex odor representations across brain states |
| topic | olfaction cortical circuits pattern completion |
| url | https://elifesciences.org/articles/53125 |
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