Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination
A 62-year-old white female with a history of early-stage triple-negative breast cancer on a combination of carboplatin and paclitaxel in the adjuvant setting presented with lower gastrointestinal bleeding. She tolerated 4 cycles of dose-dense adriamycin/cyclophosphamide with no major symptoms. After...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2017-08-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/479226 |
| _version_ | 1818972357512921088 |
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| author | Ahmed Gamal Elsayed Roma Srivastava Toni Pacioles Teresa Limjoco Maria Tria Tirona |
| author_facet | Ahmed Gamal Elsayed Roma Srivastava Toni Pacioles Teresa Limjoco Maria Tria Tirona |
| author_sort | Ahmed Gamal Elsayed |
| collection | DOAJ |
| description | A 62-year-old white female with a history of early-stage triple-negative breast cancer on a combination of carboplatin and paclitaxel in the adjuvant setting presented with lower gastrointestinal bleeding. She tolerated 4 cycles of dose-dense adriamycin/cyclophosphamide with no major symptoms. After 6 cycles of weekly paclitaxel in combination with carboplatin every 3 weeks, she presented with diarrhea and lower gastrointestinal bleeding. Colonosopic examination showed erythema and inflammation in the splenic flexure, descending colon, and sigmoid colon consistent with ischemic colitis. Pathology favored the same diagnosis. She was treated conservatively with intravenous fluids and bowel rest. Chemotherapy was held for 2 weeks and resumed after recovery without carboplatin. She was able to tolerate the remaining 6 cycles of paclitaxel with no recurrence of her symptoms. |
| first_indexed | 2024-12-20T15:06:59Z |
| format | Article |
| id | doaj.art-c9df270a6e444367bb198bbab280c02d |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-20T15:06:59Z |
| publishDate | 2017-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-c9df270a6e444367bb198bbab280c02d2022-12-21T19:36:27ZengKarger PublishersCase Reports in Oncology1662-65752017-08-0110268969310.1159/000479226479226Ischemic Colitis Associated with Paclitaxel and Carboplatin CombinationAhmed Gamal ElsayedRoma SrivastavaToni PaciolesTeresa LimjocoMaria Tria TironaA 62-year-old white female with a history of early-stage triple-negative breast cancer on a combination of carboplatin and paclitaxel in the adjuvant setting presented with lower gastrointestinal bleeding. She tolerated 4 cycles of dose-dense adriamycin/cyclophosphamide with no major symptoms. After 6 cycles of weekly paclitaxel in combination with carboplatin every 3 weeks, she presented with diarrhea and lower gastrointestinal bleeding. Colonosopic examination showed erythema and inflammation in the splenic flexure, descending colon, and sigmoid colon consistent with ischemic colitis. Pathology favored the same diagnosis. She was treated conservatively with intravenous fluids and bowel rest. Chemotherapy was held for 2 weeks and resumed after recovery without carboplatin. She was able to tolerate the remaining 6 cycles of paclitaxel with no recurrence of her symptoms.http://www.karger.com/Article/FullText/479226Ischemic colitisChemotherapy complicationsPaclitaxelCarboplatin |
| spellingShingle | Ahmed Gamal Elsayed Roma Srivastava Toni Pacioles Teresa Limjoco Maria Tria Tirona Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination Case Reports in Oncology Ischemic colitis Chemotherapy complications Paclitaxel Carboplatin |
| title | Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination |
| title_full | Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination |
| title_fullStr | Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination |
| title_full_unstemmed | Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination |
| title_short | Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination |
| title_sort | ischemic colitis associated with paclitaxel and carboplatin combination |
| topic | Ischemic colitis Chemotherapy complications Paclitaxel Carboplatin |
| url | http://www.karger.com/Article/FullText/479226 |
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