FLT3 Mutations in Acute Myeloid Leukemia: Key Concepts and Emerging Controversies

FLT3 Mutations in Acute Myeloid Leukemia: Key Concepts and Emerging Controversies

The FLT3 receptor is overexpressed on the majority of acute myeloid leukemia (AML) blasts. Mutations in FLT3 are the most common genetic alteration in AML, identified in approximately one third of newly diagnosed patients. FLT3 internal tandem duplication mutations (FLT3-ITD) are associated with inc...

Full description

Bibliographic Details
Main Authors: Vanessa E. Kennedy, Catherine C. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
Acute Myeloid Leukemia
FLT3 inhibitor
FLT3 resistance
FLT3 inhibitor maintenance
non-canonical FLT3 mutation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.612880/full

Similar Items

Similar Items