Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review
Bacterial nanocellulose (BNC, as exopolysaccharide) synthesized by some specific bacteria strains is a fascinating biopolymer composed of the three-dimensional pure cellulosic nanofibrous matrix without containing lignin, hemicellulose, pectin, and other impurities as in plant-based cellulose. Due t...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/17/4777 |
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| author | Anuj Kumar Sung-Soo Han |
| author_facet | Anuj Kumar Sung-Soo Han |
| author_sort | Anuj Kumar |
| collection | DOAJ |
| description | Bacterial nanocellulose (BNC, as exopolysaccharide) synthesized by some specific bacteria strains is a fascinating biopolymer composed of the three-dimensional pure cellulosic nanofibrous matrix without containing lignin, hemicellulose, pectin, and other impurities as in plant-based cellulose. Due to its excellent biocompatibility (in vitro and in vivo), high water-holding capacity, flexibility, high mechanical properties, and a large number of hydroxyl groups that are most similar characteristics of native tissues, BNC has shown great potential in tissue engineering applications. This review focuses on and discusses the efficacy of BNC- or BNC-based biomaterials for hard tissue regeneration. In this review, we provide brief information on the key aspects of synthesis and properties of BNC, including solubility, biodegradability, thermal stability, antimicrobial ability, toxicity, and cellular response. Further, modification approaches are discussed briefly to improve the properties of BNC or BNC-based structures. In addition, various biomaterials by using BNC (as sacrificial template or matrix) or BNC in conjugation with polymers and/or fillers are reviewed and discussed for dental and bone tissue engineering applications. Moreover, the conclusion with perspective for future research directions of using BNC for hard tissue regeneration is briefly discussed. |
| first_indexed | 2024-03-10T08:09:09Z |
| format | Article |
| id | doaj.art-c9e2d71ff1d14e07b0e768bba82204e6 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T08:09:09Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-c9e2d71ff1d14e07b0e768bba82204e62023-11-22T10:51:29ZengMDPI AGMaterials1996-19442021-08-011417477710.3390/ma14174777Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A ReviewAnuj Kumar0Sung-Soo Han1School of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, KoreaSchool of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, KoreaBacterial nanocellulose (BNC, as exopolysaccharide) synthesized by some specific bacteria strains is a fascinating biopolymer composed of the three-dimensional pure cellulosic nanofibrous matrix without containing lignin, hemicellulose, pectin, and other impurities as in plant-based cellulose. Due to its excellent biocompatibility (in vitro and in vivo), high water-holding capacity, flexibility, high mechanical properties, and a large number of hydroxyl groups that are most similar characteristics of native tissues, BNC has shown great potential in tissue engineering applications. This review focuses on and discusses the efficacy of BNC- or BNC-based biomaterials for hard tissue regeneration. In this review, we provide brief information on the key aspects of synthesis and properties of BNC, including solubility, biodegradability, thermal stability, antimicrobial ability, toxicity, and cellular response. Further, modification approaches are discussed briefly to improve the properties of BNC or BNC-based structures. In addition, various biomaterials by using BNC (as sacrificial template or matrix) or BNC in conjugation with polymers and/or fillers are reviewed and discussed for dental and bone tissue engineering applications. Moreover, the conclusion with perspective for future research directions of using BNC for hard tissue regeneration is briefly discussed.https://www.mdpi.com/1996-1944/14/17/4777bacterial cellulosenanocellulosebone tissue regenerationadditive manufacturingnatural polymersbiodegradation |
| spellingShingle | Anuj Kumar Sung-Soo Han Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review Materials bacterial cellulose nanocellulose bone tissue regeneration additive manufacturing natural polymers biodegradation |
| title | Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review |
| title_full | Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review |
| title_fullStr | Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review |
| title_full_unstemmed | Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review |
| title_short | Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review |
| title_sort | efficacy of bacterial nanocellulose in hard tissue regeneration a review |
| topic | bacterial cellulose nanocellulose bone tissue regeneration additive manufacturing natural polymers biodegradation |
| url | https://www.mdpi.com/1996-1944/14/17/4777 |
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