Unraveling the paternal genetic structure and forensic traits of the Hui population in Liaoning Province, China using Y-chromosome analysis
Abstract The Hui people are the second-largest ethnic minority in China, and they are distributed throughout the country. A previous study explored the paternal genetic structure of the Hui population in nine different regions of China, but it overlooked the Liaoning province. In this study, we exam...
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BMC
2023-11-01
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| Series: | BMC Genomics |
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| Online Access: | https://doi.org/10.1186/s12864-023-09774-8 |
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| author | Dazhi Fu Atif Adnan Jun Yao Noura H. Aldayan Chuan-Chao Wang Cao Hongyi |
| author_facet | Dazhi Fu Atif Adnan Jun Yao Noura H. Aldayan Chuan-Chao Wang Cao Hongyi |
| author_sort | Dazhi Fu |
| collection | DOAJ |
| description | Abstract The Hui people are the second-largest ethnic minority in China, and they are distributed throughout the country. A previous study explored the paternal genetic structure of the Hui population in nine different regions of China, but it overlooked the Liaoning province. In this study, we examined the paternal genetic makeup and forensic traits of the Hui population in Liaoning province by analyzing 157 Y-chromosome single nucleotide polymorphisms (Y-SNPs) and 26 short tandem repeats (Y-STRs). We successfully genotyped 282 unrelated male individuals from the Hui population of Liaoning province using the SNaPshot® single base extension assay and Goldeneye™ Y26 system kit (PEOPLESPOT R&D, Beijing, China). The results revealed high haplotypic diversity (0.9998) and identified 46 terminal haplogroups for the Hui population. Additional analyses, such as heat maps, principal component analysis (PCA), genetic distance (FST), Multidimensional scaling (MDS) analysis, and median-joining network (MJ) analysis, showed that the Hui population could be classified into three groups: Northwest Hui populations (NWH), including Liaoning, Xinjiang, Qinghai, Gansu, Ningxia, Shaanxi, and Henan; Hui populations from Sichuan and Shandong (SSH); and Yunnan Hui populations (YNH). Pairwise genetic distance (Rst) comparisons with other Chinese populations revealed that the Hui population displayed genetic affinity with the Han population. The comprehensive understanding of the Hui population in Liaoning province, explored by Y-SNPs and Y-STRs, can be utilized to interpret their genetic structure and enhance the accuracy of forensic databases. |
| first_indexed | 2024-03-10T22:15:46Z |
| format | Article |
| id | doaj.art-c9e4b4378c3d47fb969b991740ebe266 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-03-10T22:15:46Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-c9e4b4378c3d47fb969b991740ebe2662023-11-19T12:27:22ZengBMCBMC Genomics1471-21642023-11-0124111010.1186/s12864-023-09774-8Unraveling the paternal genetic structure and forensic traits of the Hui population in Liaoning Province, China using Y-chromosome analysisDazhi Fu0Atif Adnan1Jun Yao2Noura H. Aldayan3Chuan-Chao Wang4Cao Hongyi5First Affiliated Hospital of China Medical UniversityDepartment of Forensic Sciences, Collage of Criminal Justice, Naif Arab University for Security SciencesDepartment of Forensic Biology and Genetics, School of Forensic Medicine, China Medical UniversityDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Ibn Abdulaziz UniversityDepartment of Anthropology and Ethnology, Institute of Anthropology, School of Sociology and Anthropology, Xiamen UniversityFirst Affiliated Hospital of China Medical UniversityAbstract The Hui people are the second-largest ethnic minority in China, and they are distributed throughout the country. A previous study explored the paternal genetic structure of the Hui population in nine different regions of China, but it overlooked the Liaoning province. In this study, we examined the paternal genetic makeup and forensic traits of the Hui population in Liaoning province by analyzing 157 Y-chromosome single nucleotide polymorphisms (Y-SNPs) and 26 short tandem repeats (Y-STRs). We successfully genotyped 282 unrelated male individuals from the Hui population of Liaoning province using the SNaPshot® single base extension assay and Goldeneye™ Y26 system kit (PEOPLESPOT R&D, Beijing, China). The results revealed high haplotypic diversity (0.9998) and identified 46 terminal haplogroups for the Hui population. Additional analyses, such as heat maps, principal component analysis (PCA), genetic distance (FST), Multidimensional scaling (MDS) analysis, and median-joining network (MJ) analysis, showed that the Hui population could be classified into three groups: Northwest Hui populations (NWH), including Liaoning, Xinjiang, Qinghai, Gansu, Ningxia, Shaanxi, and Henan; Hui populations from Sichuan and Shandong (SSH); and Yunnan Hui populations (YNH). Pairwise genetic distance (Rst) comparisons with other Chinese populations revealed that the Hui population displayed genetic affinity with the Han population. The comprehensive understanding of the Hui population in Liaoning province, explored by Y-SNPs and Y-STRs, can be utilized to interpret their genetic structure and enhance the accuracy of forensic databases.https://doi.org/10.1186/s12864-023-09774-8Hui peopleY-SNPs and STRsLiaoning provincePaternal genetic makeupForensic traits |
| spellingShingle | Dazhi Fu Atif Adnan Jun Yao Noura H. Aldayan Chuan-Chao Wang Cao Hongyi Unraveling the paternal genetic structure and forensic traits of the Hui population in Liaoning Province, China using Y-chromosome analysis BMC Genomics Hui people Y-SNPs and STRs Liaoning province Paternal genetic makeup Forensic traits |
| title | Unraveling the paternal genetic structure and forensic traits of the Hui population in Liaoning Province, China using Y-chromosome analysis |
| title_full | Unraveling the paternal genetic structure and forensic traits of the Hui population in Liaoning Province, China using Y-chromosome analysis |
| title_fullStr | Unraveling the paternal genetic structure and forensic traits of the Hui population in Liaoning Province, China using Y-chromosome analysis |
| title_full_unstemmed | Unraveling the paternal genetic structure and forensic traits of the Hui population in Liaoning Province, China using Y-chromosome analysis |
| title_short | Unraveling the paternal genetic structure and forensic traits of the Hui population in Liaoning Province, China using Y-chromosome analysis |
| title_sort | unraveling the paternal genetic structure and forensic traits of the hui population in liaoning province china using y chromosome analysis |
| topic | Hui people Y-SNPs and STRs Liaoning province Paternal genetic makeup Forensic traits |
| url | https://doi.org/10.1186/s12864-023-09774-8 |
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