Female Antibodies Go the Distance against Influenza Viruses
ABSTRACT Females have long been described to generate superior humoral immune responses relative to those in males. In the article by Ursin et al. (R. L. Ursin, S. Dhakal, H. Liu, S. Jayaraman, et al., mBio 13:e01839-22, 2022, https://doi.org/10.1128/mbio.01839-22), the authors showed that female mi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2022-10-01
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| Series: | mBio |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mbio.02106-22 |
| _version_ | 1797989790589648896 |
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| author | Marina R. Good Jenna J. Guthmiller |
| author_facet | Marina R. Good Jenna J. Guthmiller |
| author_sort | Marina R. Good |
| collection | DOAJ |
| description | ABSTRACT Females have long been described to generate superior humoral immune responses relative to those in males. In the article by Ursin et al. (R. L. Ursin, S. Dhakal, H. Liu, S. Jayaraman, et al., mBio 13:e01839-22, 2022, https://doi.org/10.1128/mbio.01839-22), the authors showed that female mice generated a more robust, broadly reactive, and protective humoral immune response against influenza viruses in comparison to their male counterparts. Female mice demonstrated more efficient germinal center responses, including increased class switching and affinity maturation. Therefore, sex plays an important role in acquisition of protection against influenza viruses by modulating the generation of protective B cell responses. In this commentary, we dive into how this study builds on our understanding of how females generate superior antibody responses against influenza viruses and how this informs vaccine design. |
| first_indexed | 2024-04-11T08:26:10Z |
| format | Article |
| id | doaj.art-c9e756e574c344f98f2080ea9aa846ba |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-04-11T08:26:10Z |
| publishDate | 2022-10-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-c9e756e574c344f98f2080ea9aa846ba2022-12-22T04:34:47ZengAmerican Society for MicrobiologymBio2150-75112022-10-0113510.1128/mbio.02106-22Female Antibodies Go the Distance against Influenza VirusesMarina R. Good0Jenna J. Guthmiller1Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USADepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAABSTRACT Females have long been described to generate superior humoral immune responses relative to those in males. In the article by Ursin et al. (R. L. Ursin, S. Dhakal, H. Liu, S. Jayaraman, et al., mBio 13:e01839-22, 2022, https://doi.org/10.1128/mbio.01839-22), the authors showed that female mice generated a more robust, broadly reactive, and protective humoral immune response against influenza viruses in comparison to their male counterparts. Female mice demonstrated more efficient germinal center responses, including increased class switching and affinity maturation. Therefore, sex plays an important role in acquisition of protection against influenza viruses by modulating the generation of protective B cell responses. In this commentary, we dive into how this study builds on our understanding of how females generate superior antibody responses against influenza viruses and how this informs vaccine design.https://journals.asm.org/doi/10.1128/mbio.02106-22biological response modifiershumoral immunityinfluenzainfluenza vaccinesneutralizing antibodies |
| spellingShingle | Marina R. Good Jenna J. Guthmiller Female Antibodies Go the Distance against Influenza Viruses mBio biological response modifiers humoral immunity influenza influenza vaccines neutralizing antibodies |
| title | Female Antibodies Go the Distance against Influenza Viruses |
| title_full | Female Antibodies Go the Distance against Influenza Viruses |
| title_fullStr | Female Antibodies Go the Distance against Influenza Viruses |
| title_full_unstemmed | Female Antibodies Go the Distance against Influenza Viruses |
| title_short | Female Antibodies Go the Distance against Influenza Viruses |
| title_sort | female antibodies go the distance against influenza viruses |
| topic | biological response modifiers humoral immunity influenza influenza vaccines neutralizing antibodies |
| url | https://journals.asm.org/doi/10.1128/mbio.02106-22 |
| work_keys_str_mv | AT marinargood femaleantibodiesgothedistanceagainstinfluenzaviruses AT jennajguthmiller femaleantibodiesgothedistanceagainstinfluenzaviruses |