Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

Abstract Background Prionoid transmission of α-synuclein (αSyn) aggregates along neuroanatomically connected projections is posited to underlie disease progression in α-synucleinopathies. Here, we specifically wanted to study whether this prionoid progression occurs via direct inter-neuronal transfe...

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Bibliographic Details
Main Authors: Zachary A. Sorrentino, Mieu M.T. Brooks, Vincent Hudson, Nicola J. Rutherford, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Molecular Neurodegeneration
Subjects:
α-synuclein
Amyloid
Prion
Striatum
Dopaminergic Neurodegeneration
Astrocyte
Online Access:http://link.springer.com/article/10.1186/s13024-017-0182-z

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