Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight
Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD<sup>+</sup>)-dependent post-translational modification that is found on proteins as well as on nucleic acids. While ARTD1/PARP1-mediated poly-ADP-ribosylation has extensively been studied in the past 60...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/3/680 |
| _version_ | 1827697302570008576 |
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| author | Ann-Katrin Hopp Michael O. Hottiger |
| author_facet | Ann-Katrin Hopp Michael O. Hottiger |
| author_sort | Ann-Katrin Hopp |
| collection | DOAJ |
| description | Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD<sup>+</sup>)-dependent post-translational modification that is found on proteins as well as on nucleic acids. While ARTD1/PARP1-mediated poly-ADP-ribosylation has extensively been studied in the past 60 years, comparably little is known about the physiological function of mono-ADP-ribosylation and the enzymes involved in its turnover. Promising technological advances have enabled the development of innovative tools to detect NAD<sup>+</sup> and NAD<sup>+</sup>/NADH (H for hydrogen) ratios as well as ADP-ribosylation. These tools have significantly enhanced our current understanding of how intracellular NAD dynamics contribute to the regulation of ADP-ribosylation as well as to how mono-ADP-ribosylation integrates into various cellular processes. Here, we discuss the recent technological advances, as well as associated new biological findings and concepts. |
| first_indexed | 2024-03-10T13:06:11Z |
| format | Article |
| id | doaj.art-c9e8d5b7c92148b7b84b11954238e191 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T13:06:11Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c9e8d5b7c92148b7b84b11954238e1912023-11-21T11:10:00ZengMDPI AGCells2073-44092021-03-0110368010.3390/cells10030680Uncovering the Invisible: Mono-ADP-ribosylation Moved into the SpotlightAnn-Katrin Hopp0Michael O. Hottiger1Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, SwitzerlandDepartment of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, SwitzerlandAdenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD<sup>+</sup>)-dependent post-translational modification that is found on proteins as well as on nucleic acids. While ARTD1/PARP1-mediated poly-ADP-ribosylation has extensively been studied in the past 60 years, comparably little is known about the physiological function of mono-ADP-ribosylation and the enzymes involved in its turnover. Promising technological advances have enabled the development of innovative tools to detect NAD<sup>+</sup> and NAD<sup>+</sup>/NADH (H for hydrogen) ratios as well as ADP-ribosylation. These tools have significantly enhanced our current understanding of how intracellular NAD dynamics contribute to the regulation of ADP-ribosylation as well as to how mono-ADP-ribosylation integrates into various cellular processes. Here, we discuss the recent technological advances, as well as associated new biological findings and concepts.https://www.mdpi.com/2073-4409/10/3/680NADNADHADP-riboseADP-ribosylationMARylationPARylation |
| spellingShingle | Ann-Katrin Hopp Michael O. Hottiger Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight Cells NAD NADH ADP-ribose ADP-ribosylation MARylation PARylation |
| title | Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight |
| title_full | Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight |
| title_fullStr | Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight |
| title_full_unstemmed | Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight |
| title_short | Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight |
| title_sort | uncovering the invisible mono adp ribosylation moved into the spotlight |
| topic | NAD NADH ADP-ribose ADP-ribosylation MARylation PARylation |
| url | https://www.mdpi.com/2073-4409/10/3/680 |
| work_keys_str_mv | AT annkatrinhopp uncoveringtheinvisiblemonoadpribosylationmovedintothespotlight AT michaelohottiger uncoveringtheinvisiblemonoadpribosylationmovedintothespotlight |