Selective Non-toxics Inhibitors Targeting DHFR for Tuberculosis and Cancer Therapy: Pharmacophore Generation and Molecular Dynamics Simulation

Selective Non-toxics Inhibitors Targeting DHFR for Tuberculosis and Cancer Therapy: Pharmacophore Generation and Molecular Dynamics Simulation

Dihydrofolate reductase (DHFR) is a crucial enzyme that catalyzes the conversion of folic acid. Its reserved properties and significance in both human (h-DHFR) and mycobacterium (mt-DHFR) make it a challenging target for developing drugs against cancer and bacterial infections. Although methotrexate...

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Bibliographic Details
Main Authors: Ghyzlane EL Haddoumi, Mariam Mansouri, Houda Bendani, Mohammed Walid Chemao-Elfihri, Jouhaina Kourou, Hanane Abbou, Lahcen Belyamani, Ilham Kandoussi, Azeddine Ibrahimi
Format: Article
Language:English
Published: SAGE Publishing 2023-05-01
Series:Bioinformatics and Biology Insights
Online Access:https://doi.org/10.1177/11779322231171778

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