Evaluating the Effects of Subnormothermic Perfusion with AP39 in a Novel Blood-Free Model of Ex Vivo Kidney Preservation and Reperfusion

Evaluating the Effects of Subnormothermic Perfusion with AP39 in a Novel Blood-Free Model of Ex Vivo Kidney Preservation and Reperfusion

The use of blood for normothermic and subnormothermic kidney preservation hinders the translation of these approaches and promising therapeutics. This study evaluates whether adding hydrogen sulfide donor AP39 to Hemopure, a blood substitute, during subnormothermic perfusion improves kidney outcomes...

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Bibliographic Details
Main Authors: Smriti Juriasingani, Ashley Jackson, Max Yulin Zhang, Aushanth Ruthirakanthan, George J. Dugbartey, Emrullah Sogutdelen, Max Levine, Moaath Mandurah, Matthew Whiteman, Patrick Luke, Alp Sener
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
kidney preservation
kidney transplantation
hydrogen sulfide (H<sub>2</sub>S)
AP39
donation after cardiac death (DCD)
subnormothermic
Online Access:https://www.mdpi.com/1422-0067/22/13/7180

Internet

https://www.mdpi.com/1422-0067/22/13/7180

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