The Impact of Low Cardiac Output on Propofol Pharmacokinetics across Age Groups—An Investigation Using Physiologically Based Pharmacokinetic Modelling

The Impact of Low Cardiac Output on Propofol Pharmacokinetics across Age Groups—An Investigation Using Physiologically Based Pharmacokinetic Modelling

Background: pathophysiological changes such as low cardiac output (LCO) impact pharmacokinetics, but its extent may be different throughout pediatrics compared to adults. Physiologically based pharmacokinetic (PBPK) modelling enables further exploration. Methods: A validated propofol model was used...

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Bibliographic Details
Main Authors: Karel Allegaert, Mohammad Yaseen Abbasi, Robin Michelet, Olusola Olafuyi
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceutics
Subjects:
physiologically based pharmacokinetic modelling
propofol
low cardiac output
pharmacokinetics
neonate
developmental pharmacology
Online Access:https://www.mdpi.com/1999-4923/14/9/1957

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