Aggression in ADHD: relation to salivary cortisol
Abstract Background Study of cortisol levels in patients with ADHD in correlation with aggressive behaviors associated with ADHD has received limited research attention. This factor is essential for comprehending the psychopathophysiology of ADHD and its comorbidities. The present study aimed to inv...
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SpringerOpen
2021-05-01
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Series: | Middle East Current Psychiatry |
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Online Access: | https://doi.org/10.1186/s43045-021-00104-w |
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author | Reem H. El Ghamry Mona M. Mohamed Hanan M. Azzam Mahmoud M. Elhabiby Haytham M. Hasan Adel F. Hashish Mohammed M. Elhamshary Doaa M. H. Barakat |
author_facet | Reem H. El Ghamry Mona M. Mohamed Hanan M. Azzam Mahmoud M. Elhabiby Haytham M. Hasan Adel F. Hashish Mohammed M. Elhamshary Doaa M. H. Barakat |
author_sort | Reem H. El Ghamry |
collection | DOAJ |
description | Abstract Background Study of cortisol levels in patients with ADHD in correlation with aggressive behaviors associated with ADHD has received limited research attention. This factor is essential for comprehending the psychopathophysiology of ADHD and its comorbidities. The present study aimed to investigate the cortisol level in ADHD children and its relation to severity of symptoms and associated aggressive behavior in those children. The sample consisted of 129 patients and 80 healthy controls evaluated by administering the Mini International Neuropsychiatric Interview for Children, The Wechsler Intelligence Scale for Children, Conners’ parent rating scale, problem scale of C.B.C.L., and Socioeconomic Status Scale. Salivary cortisol was measured using radio-immune assay. Results Salivary cortisol level in our ADHD subjects was significantly lower (11.826 ng/ml) than in the control group (19.619 ng/ml with P-value 0.001). Our results failed to find any correlation between ADHD symptoms severity and salivary cortisol levels. Severity of delinquent, aggressive, and externalizing behaviors of ADHD children positively correlated with cortisol salivary levels. Conclusion Salivary cortisol levels are lower in children with ADHD relative to age- and sex-matched healthy controls. In addition, there is no obvious correlation between severity of ADHD symptoms and basal salivary cortisol levels. We also concluded that there is positive correlation between delinquent, aggressive, and externalizing behaviors in children with ADHD and their basal salivary cortisol levels. |
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id | doaj.art-c9ee9546d31c4666ab98187bf9f84789 |
institution | Directory Open Access Journal |
issn | 2090-5416 |
language | English |
last_indexed | 2024-12-21T21:19:44Z |
publishDate | 2021-05-01 |
publisher | SpringerOpen |
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series | Middle East Current Psychiatry |
spelling | doaj.art-c9ee9546d31c4666ab98187bf9f847892022-12-21T18:49:55ZengSpringerOpenMiddle East Current Psychiatry2090-54162021-05-012811810.1186/s43045-021-00104-wAggression in ADHD: relation to salivary cortisolReem H. El Ghamry0Mona M. Mohamed1Hanan M. Azzam2Mahmoud M. Elhabiby3Haytham M. Hasan4Adel F. Hashish5Mohammed M. Elhamshary6Doaa M. H. Barakat7Okasha Institute of Psychiatry, Faculty of Medicine, Ain Shams UniversityOkasha Institute of Psychiatry, Faculty of Medicine, Ain Shams UniversityOkasha Institute of Psychiatry, Faculty of Medicine, Ain Shams UniversityOkasha Institute of Psychiatry, Faculty of Medicine, Ain Shams UniversityFaculty of Medicine, Helwan UniversityCentre of Excellence of Medical Research, Medical Division, National Research CentreNorthumberland, Tyne and Wear NHS Trust: Cumbria, Northumberland, Tyne and Wear NHS Foundation TrustOkasha Institute of Psychiatry, Faculty of Medicine, Ain Shams UniversityAbstract Background Study of cortisol levels in patients with ADHD in correlation with aggressive behaviors associated with ADHD has received limited research attention. This factor is essential for comprehending the psychopathophysiology of ADHD and its comorbidities. The present study aimed to investigate the cortisol level in ADHD children and its relation to severity of symptoms and associated aggressive behavior in those children. The sample consisted of 129 patients and 80 healthy controls evaluated by administering the Mini International Neuropsychiatric Interview for Children, The Wechsler Intelligence Scale for Children, Conners’ parent rating scale, problem scale of C.B.C.L., and Socioeconomic Status Scale. Salivary cortisol was measured using radio-immune assay. Results Salivary cortisol level in our ADHD subjects was significantly lower (11.826 ng/ml) than in the control group (19.619 ng/ml with P-value 0.001). Our results failed to find any correlation between ADHD symptoms severity and salivary cortisol levels. Severity of delinquent, aggressive, and externalizing behaviors of ADHD children positively correlated with cortisol salivary levels. Conclusion Salivary cortisol levels are lower in children with ADHD relative to age- and sex-matched healthy controls. In addition, there is no obvious correlation between severity of ADHD symptoms and basal salivary cortisol levels. We also concluded that there is positive correlation between delinquent, aggressive, and externalizing behaviors in children with ADHD and their basal salivary cortisol levels.https://doi.org/10.1186/s43045-021-00104-wADHDAggressionSalivary cortisolAttention deficitHyperactivity |
spellingShingle | Reem H. El Ghamry Mona M. Mohamed Hanan M. Azzam Mahmoud M. Elhabiby Haytham M. Hasan Adel F. Hashish Mohammed M. Elhamshary Doaa M. H. Barakat Aggression in ADHD: relation to salivary cortisol Middle East Current Psychiatry ADHD Aggression Salivary cortisol Attention deficit Hyperactivity |
title | Aggression in ADHD: relation to salivary cortisol |
title_full | Aggression in ADHD: relation to salivary cortisol |
title_fullStr | Aggression in ADHD: relation to salivary cortisol |
title_full_unstemmed | Aggression in ADHD: relation to salivary cortisol |
title_short | Aggression in ADHD: relation to salivary cortisol |
title_sort | aggression in adhd relation to salivary cortisol |
topic | ADHD Aggression Salivary cortisol Attention deficit Hyperactivity |
url | https://doi.org/10.1186/s43045-021-00104-w |
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