Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of <i>C. asiatica</i> Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity

Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of <i>C. asiatica</i> Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity

Rapid screening of botanical extracts for the discovery of bioactive natural products was performed using a fractionation approach in conjunction with flow-injection high-resolution mass spectrometry for obtaining chemical fingerprints of each fraction, enabling the correlation of the relative abund...

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Bibliographic Details
Main Authors: Armando Alcázar Magaña, Ashish Vaswani, Kevin S. Brown, Yuan Jiang, Md Nure Alam, Maya Caruso, Parnian Lak, Paul Cheong, Nora E. Gray, Joseph F. Quinn, Amala Soumyanath, Jan F. Stevens, Claudia S. Maier
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
<i>Centella asiatica</i>
bioactives
bioassays
neuroprotection
computational methods
Elastic Net
Online Access:https://www.mdpi.com/1420-3049/29/4/838

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