Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels

Background. Syphilis is one of the important blood transfusion disease that has 3 stages and characterized by latency phase. The goal of this study is detection of demographic categories related to syphilis and cell-mediated immunity in denotation of gamma interferon. Methods. The study was done in...

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Main Authors: Saad A. Atiyah, Essra D. Taher, Younus A. Kamil, Alyaa A. Hafedh, Ali Hussein Al-Marzoqi
Format: Article
Language:English
Published: Amaltea Medical Publishing House 2023-12-01
Series:Romanian Journal of Infectious Diseases
Subjects:
Online Access:https://rjid.com.ro/articles/2023.4/RJID_2023_4_Art-03.pdf
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author Saad A. Atiyah
Essra D. Taher
Younus A. Kamil
Alyaa A. Hafedh
Ali Hussein Al-Marzoqi
author_facet Saad A. Atiyah
Essra D. Taher
Younus A. Kamil
Alyaa A. Hafedh
Ali Hussein Al-Marzoqi
author_sort Saad A. Atiyah
collection DOAJ
description Background. Syphilis is one of the important blood transfusion disease that has 3 stages and characterized by latency phase. The goal of this study is detection of demographic categories related to syphilis and cell-mediated immunity in denotation of gamma interferon. Methods. The study was done in the main blood bank in Thi-Qar province-Iraq during the period from January 2020 to December 2021, the demographic data including age, gender, address and occupation. The infection was diagnosed by using TPHA technique, while gamma interferon concentration was detected by ELISA technique according to the manufacturer instruction. Results. The study record low level of syphilis (0.5438%) among blood donors, high significant differences in the parameters of study, the age group 31-40 revealed high percent of infection (44%) and high percent of infection occur in male (99.7%). Also, high significant differences were recorded in distribution of infected donors according to occupation, where gainers (72.5%) represent the most infected group than others and the blood donors that inhabits urban area (70.19%) were most exposed to syphilis infections than those in rural areas. The IFN-γ level was high significance in the infected donors (19.651±9.009) when compared with the controls under (p value= 0.000). Conclusion. In brief, syphilis has low prevalence among blood donors in Iraqi community, with significant differences among categories of demographic data. The study revealed strong cell-mediated immune response in infected blood donors characterized by high levels of gamma interferon.
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spelling doaj.art-c9ef5b693ca94e9bbcbf03c4ace62e252024-03-21T10:03:46ZengAmaltea Medical Publishing HouseRomanian Journal of Infectious Diseases1454-33892069-60512023-12-0126414114410.37897/RJID.2023.4.3Detection of secondary syphilis among blood donors and evaluation of gamma interferon levelsSaad A. Atiyah0Essra D. Taher1Younus A. Kamil2Alyaa A. Hafedh3Ali Hussein Al-Marzoqi4Department of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar, IraqDepartment of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar, IraqThi-Qar Health Directorate-Iraq, Thi-Qar, IraqDepartment of Pathological analysis, College of Sciences, University of Thi-Qar, Thi-Qar, IraqDepartment of Biology, College of Science for Women, Babylon University, Thi-Qar, IraqBackground. Syphilis is one of the important blood transfusion disease that has 3 stages and characterized by latency phase. The goal of this study is detection of demographic categories related to syphilis and cell-mediated immunity in denotation of gamma interferon. Methods. The study was done in the main blood bank in Thi-Qar province-Iraq during the period from January 2020 to December 2021, the demographic data including age, gender, address and occupation. The infection was diagnosed by using TPHA technique, while gamma interferon concentration was detected by ELISA technique according to the manufacturer instruction. Results. The study record low level of syphilis (0.5438%) among blood donors, high significant differences in the parameters of study, the age group 31-40 revealed high percent of infection (44%) and high percent of infection occur in male (99.7%). Also, high significant differences were recorded in distribution of infected donors according to occupation, where gainers (72.5%) represent the most infected group than others and the blood donors that inhabits urban area (70.19%) were most exposed to syphilis infections than those in rural areas. The IFN-γ level was high significance in the infected donors (19.651±9.009) when compared with the controls under (p value= 0.000). Conclusion. In brief, syphilis has low prevalence among blood donors in Iraqi community, with significant differences among categories of demographic data. The study revealed strong cell-mediated immune response in infected blood donors characterized by high levels of gamma interferon. https://rjid.com.ro/articles/2023.4/RJID_2023_4_Art-03.pdfsecondary syphilisrisk factorsblood safetygamma interferonblood donors
spellingShingle Saad A. Atiyah
Essra D. Taher
Younus A. Kamil
Alyaa A. Hafedh
Ali Hussein Al-Marzoqi
Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels
Romanian Journal of Infectious Diseases
secondary syphilis
risk factors
blood safety
gamma interferon
blood donors
title Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels
title_full Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels
title_fullStr Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels
title_full_unstemmed Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels
title_short Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels
title_sort detection of secondary syphilis among blood donors and evaluation of gamma interferon levels
topic secondary syphilis
risk factors
blood safety
gamma interferon
blood donors
url https://rjid.com.ro/articles/2023.4/RJID_2023_4_Art-03.pdf
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