Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels
Background. Syphilis is one of the important blood transfusion disease that has 3 stages and characterized by latency phase. The goal of this study is detection of demographic categories related to syphilis and cell-mediated immunity in denotation of gamma interferon. Methods. The study was done in...
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Format: | Article |
Language: | English |
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Amaltea Medical Publishing House
2023-12-01
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Series: | Romanian Journal of Infectious Diseases |
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Online Access: | https://rjid.com.ro/articles/2023.4/RJID_2023_4_Art-03.pdf |
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author | Saad A. Atiyah Essra D. Taher Younus A. Kamil Alyaa A. Hafedh Ali Hussein Al-Marzoqi |
author_facet | Saad A. Atiyah Essra D. Taher Younus A. Kamil Alyaa A. Hafedh Ali Hussein Al-Marzoqi |
author_sort | Saad A. Atiyah |
collection | DOAJ |
description | Background. Syphilis is one of the important blood transfusion disease that has 3 stages and characterized by latency phase. The goal of this study is detection of demographic categories related to syphilis and cell-mediated immunity in denotation of gamma interferon. Methods. The study was done in the main blood bank in Thi-Qar province-Iraq during the period from January 2020 to December 2021, the demographic data including age, gender, address and occupation. The infection was diagnosed by using TPHA technique, while gamma interferon concentration was detected by ELISA technique according to the manufacturer instruction. Results. The study record low level of syphilis (0.5438%) among blood donors, high significant differences in the parameters of study, the age group 31-40 revealed high percent of infection (44%) and high percent of infection occur in male (99.7%). Also, high significant differences were recorded in distribution of infected donors according to occupation, where gainers (72.5%) represent the most infected group than others and the blood donors that inhabits urban area (70.19%) were most exposed to syphilis infections than those in rural areas. The IFN-γ level was high significance in the infected donors (19.651±9.009) when compared with the controls under (p value= 0.000). Conclusion. In brief, syphilis has low prevalence among blood donors in Iraqi community, with significant differences among categories of demographic data. The study revealed strong cell-mediated immune response in infected blood donors characterized by high levels of gamma interferon. |
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id | doaj.art-c9ef5b693ca94e9bbcbf03c4ace62e25 |
institution | Directory Open Access Journal |
issn | 1454-3389 2069-6051 |
language | English |
last_indexed | 2024-04-24T21:39:49Z |
publishDate | 2023-12-01 |
publisher | Amaltea Medical Publishing House |
record_format | Article |
series | Romanian Journal of Infectious Diseases |
spelling | doaj.art-c9ef5b693ca94e9bbcbf03c4ace62e252024-03-21T10:03:46ZengAmaltea Medical Publishing HouseRomanian Journal of Infectious Diseases1454-33892069-60512023-12-0126414114410.37897/RJID.2023.4.3Detection of secondary syphilis among blood donors and evaluation of gamma interferon levelsSaad A. Atiyah0Essra D. Taher1Younus A. Kamil2Alyaa A. Hafedh3Ali Hussein Al-Marzoqi4Department of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar, IraqDepartment of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar, IraqThi-Qar Health Directorate-Iraq, Thi-Qar, IraqDepartment of Pathological analysis, College of Sciences, University of Thi-Qar, Thi-Qar, IraqDepartment of Biology, College of Science for Women, Babylon University, Thi-Qar, IraqBackground. Syphilis is one of the important blood transfusion disease that has 3 stages and characterized by latency phase. The goal of this study is detection of demographic categories related to syphilis and cell-mediated immunity in denotation of gamma interferon. Methods. The study was done in the main blood bank in Thi-Qar province-Iraq during the period from January 2020 to December 2021, the demographic data including age, gender, address and occupation. The infection was diagnosed by using TPHA technique, while gamma interferon concentration was detected by ELISA technique according to the manufacturer instruction. Results. The study record low level of syphilis (0.5438%) among blood donors, high significant differences in the parameters of study, the age group 31-40 revealed high percent of infection (44%) and high percent of infection occur in male (99.7%). Also, high significant differences were recorded in distribution of infected donors according to occupation, where gainers (72.5%) represent the most infected group than others and the blood donors that inhabits urban area (70.19%) were most exposed to syphilis infections than those in rural areas. The IFN-γ level was high significance in the infected donors (19.651±9.009) when compared with the controls under (p value= 0.000). Conclusion. In brief, syphilis has low prevalence among blood donors in Iraqi community, with significant differences among categories of demographic data. The study revealed strong cell-mediated immune response in infected blood donors characterized by high levels of gamma interferon. https://rjid.com.ro/articles/2023.4/RJID_2023_4_Art-03.pdfsecondary syphilisrisk factorsblood safetygamma interferonblood donors |
spellingShingle | Saad A. Atiyah Essra D. Taher Younus A. Kamil Alyaa A. Hafedh Ali Hussein Al-Marzoqi Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels Romanian Journal of Infectious Diseases secondary syphilis risk factors blood safety gamma interferon blood donors |
title | Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels |
title_full | Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels |
title_fullStr | Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels |
title_full_unstemmed | Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels |
title_short | Detection of secondary syphilis among blood donors and evaluation of gamma interferon levels |
title_sort | detection of secondary syphilis among blood donors and evaluation of gamma interferon levels |
topic | secondary syphilis risk factors blood safety gamma interferon blood donors |
url | https://rjid.com.ro/articles/2023.4/RJID_2023_4_Art-03.pdf |
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