The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer
Introduction: Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory breast disease that can clinically and radiographically mimic breast carcinoma and bacterial mastitis. The aim of this study is to investigate the importance of levels of the inflammation markers, interleukin-33 (IL-...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-07-01
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| Series: | Journal of Investigative Surgery |
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| Online Access: | http://dx.doi.org/10.1080/08941939.2016.1240270 |
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| author | Mehmet Rafet Yigitbasi Gulcan Guntas Tuba Atak Cigdem Sonmez Haydar Yalman Hafize Uzun |
| author_facet | Mehmet Rafet Yigitbasi Gulcan Guntas Tuba Atak Cigdem Sonmez Haydar Yalman Hafize Uzun |
| author_sort | Mehmet Rafet Yigitbasi |
| collection | DOAJ |
| description | Introduction: Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory breast disease that can clinically and radiographically mimic breast carcinoma and bacterial mastitis. The aim of this study is to investigate the importance of levels of the inflammation markers, interleukin-33 (IL-33), soluble ST2 receptor of IL-33 (sST2), procalcitonin (PCT), and CRP on differential diagnosis of IGM and breast cancer (BC). Methods: 25 patients with IGM and 32 patients with primary BC who applied to General Surgery Clinic, and 30 healthy volunteer women with similar demographic condition were enrolled in the study. While the IL-33, sST2, and PCT levels were measured with ELISA method, other biochemical parameters were studied with autoanalyzer. Results: IL-33, sST2 levels were significantly higher in both BC and IGM groups than in control (p < 0.001). More importantly, the IL-33 levels of IGM group were found to be significantly higher when compared to the group with BC (p < 0.001). Accordingly the sST2 levels of the patients with IGM were significantly lower than the patients with BC (p < 0.001). There was no statistical significance between PCT levels BC and IGM groups (p > 0.05). Conclusion: The results of our study suggest that measurement of IL-33 and its receptor sST2 levels, alongside radiological studies can help distinguishing IGM from BC. Findings of our study need to be supported with additional studies. |
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| format | Article |
| id | doaj.art-c9f012b7df814bbdbd63b8f09fae22f0 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:32:32Z |
| publishDate | 2017-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-c9f012b7df814bbdbd63b8f09fae22f02023-09-15T10:12:26ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532017-07-0130427227610.1080/08941939.2016.12402701240270The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast CancerMehmet Rafet Yigitbasi0Gulcan Guntas1Tuba Atak2Cigdem Sonmez3Haydar Yalman4Hafize Uzun5Kirklareli UniversityKirklareli UniversityGoztepe Education and Research HospitalDr. AbdurahmanYurtarslan Oncology Education and Research HospitalGoztepe Education and Research HospitalCerrahpasa Medical Faculty, Istanbul UniversityIntroduction: Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory breast disease that can clinically and radiographically mimic breast carcinoma and bacterial mastitis. The aim of this study is to investigate the importance of levels of the inflammation markers, interleukin-33 (IL-33), soluble ST2 receptor of IL-33 (sST2), procalcitonin (PCT), and CRP on differential diagnosis of IGM and breast cancer (BC). Methods: 25 patients with IGM and 32 patients with primary BC who applied to General Surgery Clinic, and 30 healthy volunteer women with similar demographic condition were enrolled in the study. While the IL-33, sST2, and PCT levels were measured with ELISA method, other biochemical parameters were studied with autoanalyzer. Results: IL-33, sST2 levels were significantly higher in both BC and IGM groups than in control (p < 0.001). More importantly, the IL-33 levels of IGM group were found to be significantly higher when compared to the group with BC (p < 0.001). Accordingly the sST2 levels of the patients with IGM were significantly lower than the patients with BC (p < 0.001). There was no statistical significance between PCT levels BC and IGM groups (p > 0.05). Conclusion: The results of our study suggest that measurement of IL-33 and its receptor sST2 levels, alongside radiological studies can help distinguishing IGM from BC. Findings of our study need to be supported with additional studies.http://dx.doi.org/10.1080/08941939.2016.1240270idiopathic granulomatous mastitisinflammation markersinterleukin-33sst2 receptorprocalcitonincrp |
| spellingShingle | Mehmet Rafet Yigitbasi Gulcan Guntas Tuba Atak Cigdem Sonmez Haydar Yalman Hafize Uzun The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer Journal of Investigative Surgery idiopathic granulomatous mastitis inflammation markers interleukin-33 sst2 receptor procalcitonin crp |
| title | The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer |
| title_full | The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer |
| title_fullStr | The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer |
| title_full_unstemmed | The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer |
| title_short | The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer |
| title_sort | role of interleukin 33 as an inflammatory marker in differential diagnosis of idiopathic granulomatous mastitis and breast cancer |
| topic | idiopathic granulomatous mastitis inflammation markers interleukin-33 sst2 receptor procalcitonin crp |
| url | http://dx.doi.org/10.1080/08941939.2016.1240270 |
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