Can cytokines response play a role in the treatment of fatal leptospirosis?
Background: The northern coastal regions of Iran are endemic for leptospirosis which may range from a subclinical illness to a progressively fatal disease. There has been growing evidence that inflammatory markers play a significant role in the severity and prognosis of leptospirosis. This study aim...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2022-02-01
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| Series: | Caspian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://caspjim.com/article-1-2708-en.html |
| _version_ | 1818191986554830848 |
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| author | Ahmad Alikhani Kimia Mahmoodi Leila Delavaryan Ebrahim Salehifar Ali Reza Rafiei Mahmoud Sadeghi Zavare |
| author_facet | Ahmad Alikhani Kimia Mahmoodi Leila Delavaryan Ebrahim Salehifar Ali Reza Rafiei Mahmoud Sadeghi Zavare |
| author_sort | Ahmad Alikhani |
| collection | DOAJ |
| description | Background: The northern coastal regions of Iran are endemic for leptospirosis which may range from a subclinical illness to a progressively fatal disease. There has been growing evidence that inflammatory markers play a significant role in the severity and prognosis of leptospirosis. This study aimed to investigate inflammatory cytokines in patients with leptospirosis.
Methods: This descriptive-analytical prospective study was performed in 75 patients over 18 years old who had a positive microscopic agglutination test (MAT) titer from January to June 2019. SPSS software Version 20 was used for statistical analysis and the significance level was considered as p<0.05.
Results: The patients’ age enrolled in this study are from 21 to 75 years with a mean and standard deviation of 48.6 ± 14.0. The male to female ratio in our participants was 54/21. Fever was the most common symptoms in 66 (88.0%) patients, followed by myalgia in 62 (82.7%) cases. The level of interleukin 10 was significantly higher in severe illness (P=0.003) and fatal cases (p<0.028) compared with recovered patients. The level of TNF-α level was also higher in the severe illness and Weil's syndrome compared with the mild kind (P=0.022).
Conclusion: Our results showed that the levels of TNF-α and IL-10 significantly increased in severe leptospirosis. Also, IL-10 was significantly higher in fatal cases. The inhibition of IL-10 production might play an important role in decreasing the risk of fatal outcomes in leptospirosis. |
| first_indexed | 2024-12-12T00:23:19Z |
| format | Article |
| id | doaj.art-c9f053a060744db8803ad0797d22bee2 |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-12-12T00:23:19Z |
| publishDate | 2022-02-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-c9f053a060744db8803ad0797d22bee22022-12-22T00:44:41ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722022-02-01132343348Can cytokines response play a role in the treatment of fatal leptospirosis?Ahmad Alikhani0Kimia Mahmoodi1Leila Delavaryan2Ebrahim Salehifar3Ali Reza Rafiei4Mahmoud Sadeghi Zavare5 Department of Infectious Diseases, Antimicrobial resistance research center and communicable disease institute, Mazandaran University of Medical Sciences, Sari, Iran Department of clinical Pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol Background: The northern coastal regions of Iran are endemic for leptospirosis which may range from a subclinical illness to a progressively fatal disease. There has been growing evidence that inflammatory markers play a significant role in the severity and prognosis of leptospirosis. This study aimed to investigate inflammatory cytokines in patients with leptospirosis. Methods: This descriptive-analytical prospective study was performed in 75 patients over 18 years old who had a positive microscopic agglutination test (MAT) titer from January to June 2019. SPSS software Version 20 was used for statistical analysis and the significance level was considered as p<0.05. Results: The patients’ age enrolled in this study are from 21 to 75 years with a mean and standard deviation of 48.6 ± 14.0. The male to female ratio in our participants was 54/21. Fever was the most common symptoms in 66 (88.0%) patients, followed by myalgia in 62 (82.7%) cases. The level of interleukin 10 was significantly higher in severe illness (P=0.003) and fatal cases (p<0.028) compared with recovered patients. The level of TNF-α level was also higher in the severe illness and Weil's syndrome compared with the mild kind (P=0.022). Conclusion: Our results showed that the levels of TNF-α and IL-10 significantly increased in severe leptospirosis. Also, IL-10 was significantly higher in fatal cases. The inhibition of IL-10 production might play an important role in decreasing the risk of fatal outcomes in leptospirosis.http://caspjim.com/article-1-2708-en.htmlleptospirosisinflammatory cytokinetreatmentoutcomeil10 |
| spellingShingle | Ahmad Alikhani Kimia Mahmoodi Leila Delavaryan Ebrahim Salehifar Ali Reza Rafiei Mahmoud Sadeghi Zavare Can cytokines response play a role in the treatment of fatal leptospirosis? Caspian Journal of Internal Medicine leptospirosis inflammatory cytokine treatment outcome il10 |
| title | Can cytokines response play a role in the treatment of fatal leptospirosis? |
| title_full | Can cytokines response play a role in the treatment of fatal leptospirosis? |
| title_fullStr | Can cytokines response play a role in the treatment of fatal leptospirosis? |
| title_full_unstemmed | Can cytokines response play a role in the treatment of fatal leptospirosis? |
| title_short | Can cytokines response play a role in the treatment of fatal leptospirosis? |
| title_sort | can cytokines response play a role in the treatment of fatal leptospirosis |
| topic | leptospirosis inflammatory cytokine treatment outcome il10 |
| url | http://caspjim.com/article-1-2708-en.html |
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