Genetic variants in telomerase-associated protein 1 are associated with telomere damage in PAH-exposed workers
Telomeres are functional complexes at the ends of linear chromosomes, and telomerase aids in their maintenance and replication. Additionally, accumulating evidence suggests that telomerase-associated protein 1 (TEP1) is a component of the telomerase ribonucleoprotein complex and is responsible for c...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651321006709 |
| _version_ | 1818915720040284160 |
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| author | Xiaoran Duan Hongmei Wang Yongli Yang Pengpeng Wang Hui Zhang Bin Liu Wan Wei Wu Yao Xiaoshan Zhou Jie Zhao Wei Wang |
| author_facet | Xiaoran Duan Hongmei Wang Yongli Yang Pengpeng Wang Hui Zhang Bin Liu Wan Wei Wu Yao Xiaoshan Zhou Jie Zhao Wei Wang |
| author_sort | Xiaoran Duan |
| collection | DOAJ |
| description | Telomeres are functional complexes at the ends of linear chromosomes, and telomerase aids in their maintenance and replication. Additionally, accumulating evidence suggests that telomerase-associated protein 1 (TEP1) is a component of the telomerase ribonucleoprotein complex and is responsible for catalyzing the addition of new synthetic telomere sequences to chromosome ends. In our previous study, we found that genetic variants of the TERT gene participated in the regulation of telomere length. Exposure to particulate matter, environmental pollutants, oxidative stress, and pesticides is associated with shortening of telomere length. However, it is unknown whether genetic variants in the TEP1 gene may affect telomere length (TL) in polycyclic aromatic hydrocarbon (PAH)-exposed workers. Therefore, we measured the peripheral leukocyte TL and genotyped the polymorphism loci in the TEP1 gene among 544 PAH-exposed workers and 238 healthy controls. Covariance analysis showed that the individuals carrying TEP1 rs1760903 CC and TEP1 rs1760904 TT had longer TL in the control group (P < 0.05). In the generalized linear model, we found that rs1760903 CC was a protective factor against TL shortening, and PAH exposure could promote telomere shortening (P < 0.05). Thus, this study reinforces the roles of environmental factors and genetic variations in telomere damage, and provides a theoretical foundation for the early detection of susceptible populations and the establishment of occupational standards. |
| first_indexed | 2024-12-20T00:06:45Z |
| format | Article |
| id | doaj.art-c9f07c8ae709441a9b6567e47d74d7cd |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-20T00:06:45Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-c9f07c8ae709441a9b6567e47d74d7cd2022-12-21T20:00:38ZengElsevierEcotoxicology and Environmental Safety0147-65132021-10-01223112558Genetic variants in telomerase-associated protein 1 are associated with telomere damage in PAH-exposed workersXiaoran Duan0Hongmei Wang1Yongli Yang2Pengpeng Wang3Hui Zhang4Bin Liu5Wan Wei6Wu Yao7Xiaoshan Zhou8Jie Zhao9Wei Wang10National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China; Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of nursing, Zhengzhou Health Vocational College, Zhengzhou 450100, Henan, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaNational Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China; Correspondence to: National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Road, Erqi District, Zhengzhou 450052, China.Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China; Correspondence to: Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, No.100Kexue Road, Zhengzhou 450001, China.Telomeres are functional complexes at the ends of linear chromosomes, and telomerase aids in their maintenance and replication. Additionally, accumulating evidence suggests that telomerase-associated protein 1 (TEP1) is a component of the telomerase ribonucleoprotein complex and is responsible for catalyzing the addition of new synthetic telomere sequences to chromosome ends. In our previous study, we found that genetic variants of the TERT gene participated in the regulation of telomere length. Exposure to particulate matter, environmental pollutants, oxidative stress, and pesticides is associated with shortening of telomere length. However, it is unknown whether genetic variants in the TEP1 gene may affect telomere length (TL) in polycyclic aromatic hydrocarbon (PAH)-exposed workers. Therefore, we measured the peripheral leukocyte TL and genotyped the polymorphism loci in the TEP1 gene among 544 PAH-exposed workers and 238 healthy controls. Covariance analysis showed that the individuals carrying TEP1 rs1760903 CC and TEP1 rs1760904 TT had longer TL in the control group (P < 0.05). In the generalized linear model, we found that rs1760903 CC was a protective factor against TL shortening, and PAH exposure could promote telomere shortening (P < 0.05). Thus, this study reinforces the roles of environmental factors and genetic variations in telomere damage, and provides a theoretical foundation for the early detection of susceptible populations and the establishment of occupational standards.http://www.sciencedirect.com/science/article/pii/S0147651321006709Polycyclic aromatic hydrocarbonsTelomere lengthTEP1 geneGenetic polymorphism |
| spellingShingle | Xiaoran Duan Hongmei Wang Yongli Yang Pengpeng Wang Hui Zhang Bin Liu Wan Wei Wu Yao Xiaoshan Zhou Jie Zhao Wei Wang Genetic variants in telomerase-associated protein 1 are associated with telomere damage in PAH-exposed workers Ecotoxicology and Environmental Safety Polycyclic aromatic hydrocarbons Telomere length TEP1 gene Genetic polymorphism |
| title | Genetic variants in telomerase-associated protein 1 are associated with telomere damage in PAH-exposed workers |
| title_full | Genetic variants in telomerase-associated protein 1 are associated with telomere damage in PAH-exposed workers |
| title_fullStr | Genetic variants in telomerase-associated protein 1 are associated with telomere damage in PAH-exposed workers |
| title_full_unstemmed | Genetic variants in telomerase-associated protein 1 are associated with telomere damage in PAH-exposed workers |
| title_short | Genetic variants in telomerase-associated protein 1 are associated with telomere damage in PAH-exposed workers |
| title_sort | genetic variants in telomerase associated protein 1 are associated with telomere damage in pah exposed workers |
| topic | Polycyclic aromatic hydrocarbons Telomere length TEP1 gene Genetic polymorphism |
| url | http://www.sciencedirect.com/science/article/pii/S0147651321006709 |
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