NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation

NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation

Dysregulated redox signaling and oxidative injury are associated with inflammatory processes and fibrosis. H2O2 generation by NOX4 has been suggested as a key driver in the development of fibrosis and a small molecule drug is under evaluation in clinical trials for idiopathic pulmonary fibrosis and...

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Bibliographic Details
Main Authors: Emily Stenke, Gabriella Aviello, Ashish Singh, Sean Martin, Des Winter, Brian Sweeney, Michael McDermott, Billy Bourke, Seamus Hussey, Ulla G. Knaus
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
Intestinal inflammation
Fibrosis
Crohn's disease
NADPH oxidase
NOX4
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309575

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