Simultaneous stereoisomeric separation of loxoprofen sodium and its alcohol metabolites. Application to a stereoselective pharmacokinetic study

Simultaneous stereoisomeric separation of loxoprofen sodium and its alcohol metabolites. Application to a stereoselective pharmacokinetic study

Loxoprofen sodium (LOX) is a propionic acid derivative non-steroidal anti-inflammatory drug (NSAID), existing in the form of four stereoisomers. The main metabolites of LOX in vivo were trans- and cis-alcohol, each consisting of four stereoisomers. The objectives of the present study were to examine...

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Bibliographic Details
Main Authors:	Shirong Cao, Yanhua Fu, Bingtong Jiang, Xueli Ge, Qi Wu, Yufan Tao, Pengfei Zhao, Zhaokun Wang
Format:	Article
Language:	English
Published:	Elsevier 2023-08-01
Series:	Arabian Journal of Chemistry
Subjects:	HPLC-MS/MS Loxoprofen sodium Alcohol metabolite Rat plasma Rat urine Stereoselective behavior
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535223004045

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