A Pitx3-deficient developmental mouse model for fine motor, olfactory, and gastrointestinal symptoms of Parkinson's disease

A Pitx3-deficient developmental mouse model for fine motor, olfactory, and gastrointestinal symptoms of Parkinson's disease

Parkinson's disease (PD) is characterized by the selective death of substantia nigra pars compacta (SNpc) dopaminergic neurons and includes both motor and non-motor symptoms. While numerous models exist for the study of typical PD motor deficits, fewer exist for non-motor symptoms. Previous stu...

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Bibliographic Details
Main Authors: Bin Song, Jacob W. Feldmann, Shibo Cao, Melissa Feitosa, Youngbin Kong, Woori Kim, Altana Schweitzer, Pierre Leblanc, Jeffrey S. Schweitzer, Kwang-Soo Kim
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Pitx3
motor function
olfactory function
gastrointestinal function
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122001693

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