The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis
A chondrosarcoma is a common tumor of the soft tissue and bone that has a high propensity to metastasize to distant organs. Nerve growth factor (NGF) is capable of promoting the progression and metastasis of several different types of tumors although the effects of NGF in a chondrosarcoma are not co...
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MDPI AG
2021-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/13/3347 |
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| author | Huey-En Tzeng Syuan-Ling Lin Louis-Anoop Thadevoos Chih-Yuan Ko Ju-Fang Liu Yu-Wen Huang Chih-Yang Lin Yi-Chin Fong Chih-Hsin Tang |
| author_facet | Huey-En Tzeng Syuan-Ling Lin Louis-Anoop Thadevoos Chih-Yuan Ko Ju-Fang Liu Yu-Wen Huang Chih-Yang Lin Yi-Chin Fong Chih-Hsin Tang |
| author_sort | Huey-En Tzeng |
| collection | DOAJ |
| description | A chondrosarcoma is a common tumor of the soft tissue and bone that has a high propensity to metastasize to distant organs. Nerve growth factor (NGF) is capable of promoting the progression and metastasis of several different types of tumors although the effects of NGF in a chondrosarcoma are not confirmed. Here, we found that the levels of NGF and matrix metalloproteinase-2 (MMP-2) correlated with the tumor stage in patients with a chondrosarcoma. NGF facilitated the MMP-2-dependent cellular migration in human chondrosarcoma JJ012 cells while the overexpression of NGF enhanced the lung metastasis in a mouse model of a chondrosarcoma. NGF promoted the MMP-2 synthesis and cell migration by inhibiting miR-423-5p expression through the FAK and c-Src signaling cascades. NGF appears to be a worthwhile therapeutic target in the treatment of a metastatic chondrosarcoma. |
| first_indexed | 2024-03-10T09:53:13Z |
| format | Article |
| id | doaj.art-c9f683d5b1fb4e669210c14556856079 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:53:13Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c9f683d5b1fb4e669210c145568560792023-11-22T02:36:28ZengMDPI AGCancers2072-66942021-07-011313334710.3390/cancers13133347The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma MetastasisHuey-En Tzeng0Syuan-Ling Lin1Louis-Anoop Thadevoos2Chih-Yuan Ko3Ju-Fang Liu4Yu-Wen Huang5Chih-Yang Lin6Yi-Chin Fong7Chih-Hsin Tang8Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, TaiwanTranslational Medicine Research Center, China Medical University Hospital, Taichung 40402, TaiwanInternational Master Program of Biomedical Sciences, China Medical University, Taichung 40402, TaiwanDepartment of Orthopedic Surgery, China Medical University Hospital, Taichung 40402, TaiwanSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 11031, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, TaiwanDepartment of Pharmacology, School of Medicine, China Medical University, Taichung 40402, TaiwanDepartment of Sports Medicine, College of Health Care, China Medical University, Taichung 40402, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, TaiwanA chondrosarcoma is a common tumor of the soft tissue and bone that has a high propensity to metastasize to distant organs. Nerve growth factor (NGF) is capable of promoting the progression and metastasis of several different types of tumors although the effects of NGF in a chondrosarcoma are not confirmed. Here, we found that the levels of NGF and matrix metalloproteinase-2 (MMP-2) correlated with the tumor stage in patients with a chondrosarcoma. NGF facilitated the MMP-2-dependent cellular migration in human chondrosarcoma JJ012 cells while the overexpression of NGF enhanced the lung metastasis in a mouse model of a chondrosarcoma. NGF promoted the MMP-2 synthesis and cell migration by inhibiting miR-423-5p expression through the FAK and c-Src signaling cascades. NGF appears to be a worthwhile therapeutic target in the treatment of a metastatic chondrosarcoma.https://www.mdpi.com/2072-6694/13/13/3347NGFchondrosarcomametastasisMMP-2miR-423-5p |
| spellingShingle | Huey-En Tzeng Syuan-Ling Lin Louis-Anoop Thadevoos Chih-Yuan Ko Ju-Fang Liu Yu-Wen Huang Chih-Yang Lin Yi-Chin Fong Chih-Hsin Tang The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis Cancers NGF chondrosarcoma metastasis MMP-2 miR-423-5p |
| title | The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis |
| title_full | The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis |
| title_fullStr | The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis |
| title_full_unstemmed | The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis |
| title_short | The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis |
| title_sort | mir 423 5p mmp 2 axis regulates the nerve growth factor induced promotion of chondrosarcoma metastasis |
| topic | NGF chondrosarcoma metastasis MMP-2 miR-423-5p |
| url | https://www.mdpi.com/2072-6694/13/13/3347 |
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