Association between Biomarkers of Inflammation and 10-Year Changes in Aortic Stiffness: The Multi-Ethnic Study of Atherosclerosis
<i>Background</i>. Chronic inflammation is associated with incident cardiovascular events. We study the association between biomarkers of inflammation and subclinical vascular dysfunction measured as proximal aortic stiffness. <i>Methods.</i> MRI imaging was performed in the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/15/5062 |
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| author | Rithvik Swamynathan Vinithra Varadarajan Hieu Nguyen Colin O. Wu Kiang Liu David A. Bluemke Nadjia Kachenoura Alban Redheuil João A. C. Lima Bharath Ambale-Venkatesh |
| author_facet | Rithvik Swamynathan Vinithra Varadarajan Hieu Nguyen Colin O. Wu Kiang Liu David A. Bluemke Nadjia Kachenoura Alban Redheuil João A. C. Lima Bharath Ambale-Venkatesh |
| author_sort | Rithvik Swamynathan |
| collection | DOAJ |
| description | <i>Background</i>. Chronic inflammation is associated with incident cardiovascular events. We study the association between biomarkers of inflammation and subclinical vascular dysfunction measured as proximal aortic stiffness. <i>Methods.</i> MRI imaging was performed in the Multi-Ethnic Study of Atherosclerosis (MESA) at baseline (2000) and at the 10-year follow-up. Aortic arch pulse wave velocity (PWV) and ascending and descending aorta distensibility (AAD, DAD) were measured in 1223 asymptomatic individuals at both exams. Linear regression was used to study the association of baseline inflammation—C-reactive protein (CRP), interleukin-6 (IL6), and fibrinogen (Fib)—with baseline and 10-year changes in aortic stiffness (PWV, AAD, DAD). <i>Results</i>. The mean age of the participants was 59 ± 9 years, 47.8% of them were men, 32.6% were hypertensive at baseline, and 7.6% were diabetic. At baseline and follow-up, the mean AAD values were, respectively, 1.73 × 10<sup>−3</sup> mmHg<sup>−1</sup> and 1.57 × 10<sup>−3</sup> mmHg<sup>−1</sup>, the mean DAD values were 2.19 × 10<sup>−3</sup> mmHg<sup>−1</sup> and 1.99 × 10<sup>−3</sup> mmHg<sup>−1</sup>, and the mean PWV values were 8.10 m/s and 8.99 m/s. At baseline, the AAD (in 10<sup>−3</sup> mmHg<sup>−1</sup>) and DAD (in 10<sup>−3</sup> mmHg<sup>−1</sup>) were inversely associated with CRP (in mg/L) (AAD coeff: −0.047, <i>p</i>-value: 0.011, DAD coeff: −0.068, <i>p</i>-value: <0.001) and IL6 (in pg/mL) (AAD coeff: −0.098, <i>p</i>-value: 0.003, DAD coeff: −0.14, <i>p</i>-value: <0.001) in a univariable analysis but not after adjustment for demographic variables or cardiovascular risk factors. The baseline DAD was inversely associated with Fib (in mg/dL) (coeff: −0.334, <i>p</i>-value: 0.001). The baseline PWV (in m/s) was positively associated with IL6 (in pg/mL) in a univariable analysis (coeff: 0.054, <i>p</i>-value: 0.014). In a longitudinal analysis, the 10-year changes in DAD were inversely associated with CRP, even after adjustment for demographics and risk factors (DAD coeff: −0.08, <i>p</i>-value 0.044). <i>Conclusions.</i> Higher CRP levels at baseline were independently associated with a 10-year increase in aortic stiffness, measured as decreased aortic distensibility. |
| first_indexed | 2024-03-11T00:24:46Z |
| format | Article |
| id | doaj.art-c9f8afc6ff0d40e7922a136aae02fb88 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:24:46Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c9f8afc6ff0d40e7922a136aae02fb882023-11-18T23:08:52ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011215506210.3390/jcm12155062Association between Biomarkers of Inflammation and 10-Year Changes in Aortic Stiffness: The Multi-Ethnic Study of AtherosclerosisRithvik Swamynathan0Vinithra Varadarajan1Hieu Nguyen2Colin O. Wu3Kiang Liu4David A. Bluemke5Nadjia Kachenoura6Alban Redheuil7João A. C. Lima8Bharath Ambale-Venkatesh9Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USANational Institutes of Health, Bethesda, MD 20892, USADepartment of Preventive Medicine, Northwestern University Medical School, Chicago, IL 60622, USADepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USACNRS, INSERM, Laboratoire d’Imagerie Biomédicale, LIB, Sorbonne Université, 75006 Paris, FranceCNRS, INSERM, Laboratoire d’Imagerie Biomédicale, LIB, Sorbonne Université, 75006 Paris, FranceDepartment of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA<i>Background</i>. Chronic inflammation is associated with incident cardiovascular events. We study the association between biomarkers of inflammation and subclinical vascular dysfunction measured as proximal aortic stiffness. <i>Methods.</i> MRI imaging was performed in the Multi-Ethnic Study of Atherosclerosis (MESA) at baseline (2000) and at the 10-year follow-up. Aortic arch pulse wave velocity (PWV) and ascending and descending aorta distensibility (AAD, DAD) were measured in 1223 asymptomatic individuals at both exams. Linear regression was used to study the association of baseline inflammation—C-reactive protein (CRP), interleukin-6 (IL6), and fibrinogen (Fib)—with baseline and 10-year changes in aortic stiffness (PWV, AAD, DAD). <i>Results</i>. The mean age of the participants was 59 ± 9 years, 47.8% of them were men, 32.6% were hypertensive at baseline, and 7.6% were diabetic. At baseline and follow-up, the mean AAD values were, respectively, 1.73 × 10<sup>−3</sup> mmHg<sup>−1</sup> and 1.57 × 10<sup>−3</sup> mmHg<sup>−1</sup>, the mean DAD values were 2.19 × 10<sup>−3</sup> mmHg<sup>−1</sup> and 1.99 × 10<sup>−3</sup> mmHg<sup>−1</sup>, and the mean PWV values were 8.10 m/s and 8.99 m/s. At baseline, the AAD (in 10<sup>−3</sup> mmHg<sup>−1</sup>) and DAD (in 10<sup>−3</sup> mmHg<sup>−1</sup>) were inversely associated with CRP (in mg/L) (AAD coeff: −0.047, <i>p</i>-value: 0.011, DAD coeff: −0.068, <i>p</i>-value: <0.001) and IL6 (in pg/mL) (AAD coeff: −0.098, <i>p</i>-value: 0.003, DAD coeff: −0.14, <i>p</i>-value: <0.001) in a univariable analysis but not after adjustment for demographic variables or cardiovascular risk factors. The baseline DAD was inversely associated with Fib (in mg/dL) (coeff: −0.334, <i>p</i>-value: 0.001). The baseline PWV (in m/s) was positively associated with IL6 (in pg/mL) in a univariable analysis (coeff: 0.054, <i>p</i>-value: 0.014). In a longitudinal analysis, the 10-year changes in DAD were inversely associated with CRP, even after adjustment for demographics and risk factors (DAD coeff: −0.08, <i>p</i>-value 0.044). <i>Conclusions.</i> Higher CRP levels at baseline were independently associated with a 10-year increase in aortic stiffness, measured as decreased aortic distensibility.https://www.mdpi.com/2077-0383/12/15/5062aortadistensibilitypulse wave velocityinflammationMRI |
| spellingShingle | Rithvik Swamynathan Vinithra Varadarajan Hieu Nguyen Colin O. Wu Kiang Liu David A. Bluemke Nadjia Kachenoura Alban Redheuil João A. C. Lima Bharath Ambale-Venkatesh Association between Biomarkers of Inflammation and 10-Year Changes in Aortic Stiffness: The Multi-Ethnic Study of Atherosclerosis Journal of Clinical Medicine aorta distensibility pulse wave velocity inflammation MRI |
| title | Association between Biomarkers of Inflammation and 10-Year Changes in Aortic Stiffness: The Multi-Ethnic Study of Atherosclerosis |
| title_full | Association between Biomarkers of Inflammation and 10-Year Changes in Aortic Stiffness: The Multi-Ethnic Study of Atherosclerosis |
| title_fullStr | Association between Biomarkers of Inflammation and 10-Year Changes in Aortic Stiffness: The Multi-Ethnic Study of Atherosclerosis |
| title_full_unstemmed | Association between Biomarkers of Inflammation and 10-Year Changes in Aortic Stiffness: The Multi-Ethnic Study of Atherosclerosis |
| title_short | Association between Biomarkers of Inflammation and 10-Year Changes in Aortic Stiffness: The Multi-Ethnic Study of Atherosclerosis |
| title_sort | association between biomarkers of inflammation and 10 year changes in aortic stiffness the multi ethnic study of atherosclerosis |
| topic | aorta distensibility pulse wave velocity inflammation MRI |
| url | https://www.mdpi.com/2077-0383/12/15/5062 |
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