Bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic rats
Background: Bryophyllum pinnatum, commonly known as Pattharcaṭṭa, is used traditionally in ethnomedicinal practices for the treatment of kidney stone and urinary insufficiency. Aim: The present study evaluated the effect of Bryophyllum pinnatum on ethylene glycol (EG)-induced renal calculi in rats....
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
| Series: | Ancient Science of Life |
| Subjects: | |
| Online Access: | http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2016;volume=36;issue=2;spage=90;epage=97;aulast=Yadav |
| _version_ | 1818156537470779392 |
|---|---|
| author | Mahendra Yadav Vijay D Gulkari Manish M Wanjari |
| author_facet | Mahendra Yadav Vijay D Gulkari Manish M Wanjari |
| author_sort | Mahendra Yadav |
| collection | DOAJ |
| description | Background: Bryophyllum pinnatum, commonly known as Pattharcaṭṭa, is used traditionally in ethnomedicinal practices for the treatment of kidney stone and urinary insufficiency. Aim: The present study evaluated the effect of Bryophyllum pinnatum on ethylene glycol (EG)-induced renal calculi in rats. Materials and Methods: Renal calculi were induced in rats by administration of 0.75% EG in drinking water and co-treated orally with standard drug, Cystone (750 mg/kg), or alcoholic and hydro-alcoholic extracts in doses of 100, 200 and 400 mg/kg for 28 days. Weekly body weights were recorded. On day 29, urolithiasis was confirmed by assessing the urinary parameters (urine volume, pH, uric acid, calcium, phosphorus, oxalate, magnesium and creatinine clearance), serum biochemical parameters (creatinine, uric acid, urea, calcium, phosphorus and magnesium), oxidative stress parameters and histology of kidney. Results: Treatment with extracts attenuated the EG-induced decrease in body weight and elevation in urinary parameters (uric acid, calcium, phosphorus and oxalate) and serum biochemical parameters (creatinine, uric acid, urea, calcium, phosphorus and magnesium). Extract treatment also reversed EG-induced decrease in urine volume, pH, magnesium and creatinine clearance, oxidative and histological damages in kidneys. Results were comparable to standard drug, Cystone. Results indicated that EG administration caused renal calculi formation which is prevented by treatment with extracts. The observed antilithiatic effect may be attributed to the presence of high content of phenolics, flavonoids and saponins in the extracts. Conclusion: Bryophyllum pinnatum leaves showed preventive effect against renal calculi formation and validates its ethnomedicinal use in urinary disorders. It further supports its therapeutic potential for the treatment of urinary calculi. |
| first_indexed | 2024-12-11T14:59:52Z |
| format | Article |
| id | doaj.art-c9f8b05a126a46cfb42ee876a316593c |
| institution | Directory Open Access Journal |
| issn | 0257-7941 |
| language | English |
| last_indexed | 2024-12-11T14:59:52Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Ancient Science of Life |
| spelling | doaj.art-c9f8b05a126a46cfb42ee876a316593c2022-12-22T01:01:11ZengWolters Kluwer Medknow PublicationsAncient Science of Life0257-79412016-01-01362909710.4103/asl.ASL_90_16Bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic ratsMahendra YadavVijay D GulkariManish M WanjariBackground: Bryophyllum pinnatum, commonly known as Pattharcaṭṭa, is used traditionally in ethnomedicinal practices for the treatment of kidney stone and urinary insufficiency. Aim: The present study evaluated the effect of Bryophyllum pinnatum on ethylene glycol (EG)-induced renal calculi in rats. Materials and Methods: Renal calculi were induced in rats by administration of 0.75% EG in drinking water and co-treated orally with standard drug, Cystone (750 mg/kg), or alcoholic and hydro-alcoholic extracts in doses of 100, 200 and 400 mg/kg for 28 days. Weekly body weights were recorded. On day 29, urolithiasis was confirmed by assessing the urinary parameters (urine volume, pH, uric acid, calcium, phosphorus, oxalate, magnesium and creatinine clearance), serum biochemical parameters (creatinine, uric acid, urea, calcium, phosphorus and magnesium), oxidative stress parameters and histology of kidney. Results: Treatment with extracts attenuated the EG-induced decrease in body weight and elevation in urinary parameters (uric acid, calcium, phosphorus and oxalate) and serum biochemical parameters (creatinine, uric acid, urea, calcium, phosphorus and magnesium). Extract treatment also reversed EG-induced decrease in urine volume, pH, magnesium and creatinine clearance, oxidative and histological damages in kidneys. Results were comparable to standard drug, Cystone. Results indicated that EG administration caused renal calculi formation which is prevented by treatment with extracts. The observed antilithiatic effect may be attributed to the presence of high content of phenolics, flavonoids and saponins in the extracts. Conclusion: Bryophyllum pinnatum leaves showed preventive effect against renal calculi formation and validates its ethnomedicinal use in urinary disorders. It further supports its therapeutic potential for the treatment of urinary calculi.http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2016;volume=36;issue=2;spage=90;epage=97;aulast=YadavBryophyllum pinnatumethnomedicineethylene glycolkidney stonelithiasisurinary disorder |
| spellingShingle | Mahendra Yadav Vijay D Gulkari Manish M Wanjari Bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic rats Ancient Science of Life Bryophyllum pinnatum ethnomedicine ethylene glycol kidney stone lithiasis urinary disorder |
| title | Bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic rats |
| title_full | Bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic rats |
| title_fullStr | Bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic rats |
| title_full_unstemmed | Bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic rats |
| title_short | Bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic rats |
| title_sort | bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic rats |
| topic | Bryophyllum pinnatum ethnomedicine ethylene glycol kidney stone lithiasis urinary disorder |
| url | http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2016;volume=36;issue=2;spage=90;epage=97;aulast=Yadav |
| work_keys_str_mv | AT mahendrayadav bryophyllumpinnatumleafextractspreventformationofrenalcalculiinlithiaticrats AT vijaydgulkari bryophyllumpinnatumleafextractspreventformationofrenalcalculiinlithiaticrats AT manishmwanjari bryophyllumpinnatumleafextractspreventformationofrenalcalculiinlithiaticrats |