Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes
Control of malaria is an important global health issue and there is still an urgent need for the development of an effective prophylactic vaccine. Multiple studies have provided strong evidence that Plasmodium falciparum-specific MHC class I-restricted CD8+ T cells are important for sterile protecti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00397/full |
| _version_ | 1818287756252545024 |
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| author | Janna Heide Janna Heide Kerrie C. Vaughan Alessandro Sette Alessandro Sette Thomas Jacobs Julian Schulze zur Wiesch Julian Schulze zur Wiesch |
| author_facet | Janna Heide Janna Heide Kerrie C. Vaughan Alessandro Sette Alessandro Sette Thomas Jacobs Julian Schulze zur Wiesch Julian Schulze zur Wiesch |
| author_sort | Janna Heide |
| collection | DOAJ |
| description | Control of malaria is an important global health issue and there is still an urgent need for the development of an effective prophylactic vaccine. Multiple studies have provided strong evidence that Plasmodium falciparum-specific MHC class I-restricted CD8+ T cells are important for sterile protection against Plasmodium falciparum infection. Here, we present an interactive epitope map of all P. falciparum-specific CD8+ T cell epitopes published to date, based on a comprehensive data base (IEDB), and literature search. The majority of the described P. falciparum-specific CD8+ T cells were directed against the antigens CSP, TRAP, AMA1, and LSA1. Notably, most of the epitopes were discovered in vaccine trials conducted with malaria-naïve volunteers. Only few immunological studies of P. falciparum-specific CD8+ T cell epitopes detected in patients suffering from acute malaria or in people living in malaria endemic areas have been published. Further detailed immunological mappings of P. falciparum-specific epitopes of a broader range of P. falciparum proteins in different settings and with different disease status are needed to gain a more comprehensive understanding of the role of CD8+ T cell responses for protection, and to better guide vaccine design and to study their efficacy. |
| first_indexed | 2024-12-13T01:45:32Z |
| format | Article |
| id | doaj.art-c9faa7baf12b4906bddd2b93966486c9 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T01:45:32Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c9faa7baf12b4906bddd2b93966486c92022-12-22T00:03:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-03-011010.3389/fimmu.2019.00397437813Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell EpitopesJanna Heide0Janna Heide1Kerrie C. Vaughan2Alessandro Sette3Alessandro Sette4Thomas Jacobs5Julian Schulze zur Wiesch6Julian Schulze zur Wiesch7Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyGerman Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, GermanyDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, United StatesDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, United StatesDepartment of Medicine, Division of Infectious Diseases, University of California, San Diego (UCSD), La Jolla, CA, United StatesProtozoa Immunology, Bernhard-Nocht-Institute of Tropical Medicine, Hamburg, GermanyInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyGerman Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, GermanyControl of malaria is an important global health issue and there is still an urgent need for the development of an effective prophylactic vaccine. Multiple studies have provided strong evidence that Plasmodium falciparum-specific MHC class I-restricted CD8+ T cells are important for sterile protection against Plasmodium falciparum infection. Here, we present an interactive epitope map of all P. falciparum-specific CD8+ T cell epitopes published to date, based on a comprehensive data base (IEDB), and literature search. The majority of the described P. falciparum-specific CD8+ T cells were directed against the antigens CSP, TRAP, AMA1, and LSA1. Notably, most of the epitopes were discovered in vaccine trials conducted with malaria-naïve volunteers. Only few immunological studies of P. falciparum-specific CD8+ T cell epitopes detected in patients suffering from acute malaria or in people living in malaria endemic areas have been published. Further detailed immunological mappings of P. falciparum-specific epitopes of a broader range of P. falciparum proteins in different settings and with different disease status are needed to gain a more comprehensive understanding of the role of CD8+ T cell responses for protection, and to better guide vaccine design and to study their efficacy.https://www.frontiersin.org/article/10.3389/fimmu.2019.00397/fullmalariaPlasmodium falciparumCD8+T cell epitopeHLArestriction |
| spellingShingle | Janna Heide Janna Heide Kerrie C. Vaughan Alessandro Sette Alessandro Sette Thomas Jacobs Julian Schulze zur Wiesch Julian Schulze zur Wiesch Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes Frontiers in Immunology malaria Plasmodium falciparum CD8+ T cell epitope HLA restriction |
| title | Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes |
| title_full | Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes |
| title_fullStr | Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes |
| title_full_unstemmed | Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes |
| title_short | Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes |
| title_sort | comprehensive review of human plasmodium falciparum specific cd8 t cell epitopes |
| topic | malaria Plasmodium falciparum CD8+ T cell epitope HLA restriction |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00397/full |
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