Rapid in silico Design of Potential Cyclic Peptide Binders Targeting Protein-Protein Interfaces

Rational design of specific inhibitors of protein-protein interactions is desirable for drug design to control cellular signal transduction but also for studying protein-protein interaction networks. We have developed a rapid computational approach to rationally design cyclic peptides that potential...

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Bibliographic Details
Main Authors: Brianda L. Santini, Martin Zacharias
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.573259/full