Fertility Treatment Resulting in Live Births in Women with Asthma – Associated with Perennial Allergy?
Casper Tidemandsen,1 Anne Vejen Hansen,1 Vibeke Backer,2 Elisabeth Juul Gade,3 Zarqa Ali,4 Charlotte Suppli Ulrik1,2 1Department of Respiratory Medicine, Hvidovre Hospital, Hvidovre, Denmark; 2Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 3Department of Gynecology an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-04-01
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| Series: | Journal of Asthma and Allergy |
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| Online Access: | https://www.dovepress.com/fertility-treatment-resulting-in-live-births-in-women-with-asthma-ndas-peer-reviewed-article-JAA |
| _version_ | 1828484959400099840 |
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| author | Tidemandsen C Vejen Hansen A Backer V Gade EJ Ali Z Suppli Ulrik C |
| author_facet | Tidemandsen C Vejen Hansen A Backer V Gade EJ Ali Z Suppli Ulrik C |
| author_sort | Tidemandsen C |
| collection | DOAJ |
| description | Casper Tidemandsen,1 Anne Vejen Hansen,1 Vibeke Backer,2 Elisabeth Juul Gade,3 Zarqa Ali,4 Charlotte Suppli Ulrik1,2 1Department of Respiratory Medicine, Hvidovre Hospital, Hvidovre, Denmark; 2Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 3Department of Gynecology and Obstetrics, Rigshospitalet, Copenhagen, Denmark; 4Department of Dermatology and Wound Healing Centre, Bispebjerg Hospital, Copenhagen, DenmarkCorrespondence: Casper TidemandsenRespiratory Research Unit Hvidovre, Department of Respiratory Medicine, Hvidovre University Hospital, Kettegård Alle 30, Hvidovre DK-2650, DenmarkTel +45 50751516Email casper.tidemandsen.01@regionh.dkBackground: Asthma has been linked with prolonged time to pregnancy compared to healthy controls, also asthma has been linked to a higher need for fertility treatment. However, knowledge of the possible association between allergy and need for fertility treatment is limited. Our aim was to explore a possible difference in having had fertility treatment in women with asthma and live births in those with perennial allergy (animals, fungi and dust mites) compared to no allergy/seasonal allergy. The primary outcome of interest was fertility treatment.Patients and Methods: Women enrolled in the Management of Asthma during Pregnancy (MAP) program at Hvidovre Hospital, DK, were included in the present analysis provided they fulfilled the following criteria: 1) diagnosed with asthma and current anti-asthma therapy and 2) first visit to the respiratory outpatient clinic within the first 18 weeks of pregnancy. Participants were divided into two groups: asthma with perennial allergy (cases) and asthma with seasonal/no allergy (controls). Logistic regression analysis was applied, and findings expressed as odds ratios (OR).Results: Among women with asthma and perennial allergy (n=544 cases), 13.8% (n=75) had fertility treatment, compared to only 10.1% (n=39) among women with asthma and seasonal/no allergy (n=388, controls) (OR 1.43, 95% CI 0.95– 2.16, p=0.087). This association remained statistically insignificant after adjusting for confounders, including BMI (OR 1.19, 95% CI 0.77– 1.84, p=0.433). In women ≥ 35 years of age, 28% (n=44) and 20% (n=19), respectively, among cases and controls had fertility treatment (OR 1.60, 95% CI 0.87– 2.94, p=0.132), and likewise, statistically insignificant after adjusting for confounders (OR 1.41, 95% CI 0.74– 2.69, p< 0.293).Conclusion: In women with asthma and live births, our study revealed a trend towards an association between perennial allergy and a higher need for fertility treatment compared to seasonal/no allergy.Keywords: asthma, allergy, pregnancy, IVF, ART, fertility, atopy |
| first_indexed | 2024-12-11T09:04:48Z |
| format | Article |
| id | doaj.art-c9fb6a1e83e6467b9d77d28a85aa8044 |
| institution | Directory Open Access Journal |
| issn | 1178-6965 |
| language | English |
| last_indexed | 2024-12-11T09:04:48Z |
| publishDate | 2020-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj.art-c9fb6a1e83e6467b9d77d28a85aa80442022-12-22T01:13:40ZengDove Medical PressJournal of Asthma and Allergy1178-69652020-04-01Volume 1314515253342Fertility Treatment Resulting in Live Births in Women with Asthma – Associated with Perennial Allergy?Tidemandsen CVejen Hansen ABacker VGade EJAli ZSuppli Ulrik CCasper Tidemandsen,1 Anne Vejen Hansen,1 Vibeke Backer,2 Elisabeth Juul Gade,3 Zarqa Ali,4 Charlotte Suppli Ulrik1,2 1Department of Respiratory Medicine, Hvidovre Hospital, Hvidovre, Denmark; 2Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 3Department of Gynecology and Obstetrics, Rigshospitalet, Copenhagen, Denmark; 4Department of Dermatology and Wound Healing Centre, Bispebjerg Hospital, Copenhagen, DenmarkCorrespondence: Casper TidemandsenRespiratory Research Unit Hvidovre, Department of Respiratory Medicine, Hvidovre University Hospital, Kettegård Alle 30, Hvidovre DK-2650, DenmarkTel +45 50751516Email casper.tidemandsen.01@regionh.dkBackground: Asthma has been linked with prolonged time to pregnancy compared to healthy controls, also asthma has been linked to a higher need for fertility treatment. However, knowledge of the possible association between allergy and need for fertility treatment is limited. Our aim was to explore a possible difference in having had fertility treatment in women with asthma and live births in those with perennial allergy (animals, fungi and dust mites) compared to no allergy/seasonal allergy. The primary outcome of interest was fertility treatment.Patients and Methods: Women enrolled in the Management of Asthma during Pregnancy (MAP) program at Hvidovre Hospital, DK, were included in the present analysis provided they fulfilled the following criteria: 1) diagnosed with asthma and current anti-asthma therapy and 2) first visit to the respiratory outpatient clinic within the first 18 weeks of pregnancy. Participants were divided into two groups: asthma with perennial allergy (cases) and asthma with seasonal/no allergy (controls). Logistic regression analysis was applied, and findings expressed as odds ratios (OR).Results: Among women with asthma and perennial allergy (n=544 cases), 13.8% (n=75) had fertility treatment, compared to only 10.1% (n=39) among women with asthma and seasonal/no allergy (n=388, controls) (OR 1.43, 95% CI 0.95– 2.16, p=0.087). This association remained statistically insignificant after adjusting for confounders, including BMI (OR 1.19, 95% CI 0.77– 1.84, p=0.433). In women ≥ 35 years of age, 28% (n=44) and 20% (n=19), respectively, among cases and controls had fertility treatment (OR 1.60, 95% CI 0.87– 2.94, p=0.132), and likewise, statistically insignificant after adjusting for confounders (OR 1.41, 95% CI 0.74– 2.69, p< 0.293).Conclusion: In women with asthma and live births, our study revealed a trend towards an association between perennial allergy and a higher need for fertility treatment compared to seasonal/no allergy.Keywords: asthma, allergy, pregnancy, IVF, ART, fertility, atopyhttps://www.dovepress.com/fertility-treatment-resulting-in-live-births-in-women-with-asthma-ndas-peer-reviewed-article-JAAasthmaallergypregnancyivfartfertilityatopy |
| spellingShingle | Tidemandsen C Vejen Hansen A Backer V Gade EJ Ali Z Suppli Ulrik C Fertility Treatment Resulting in Live Births in Women with Asthma – Associated with Perennial Allergy? Journal of Asthma and Allergy asthma allergy pregnancy ivf art fertility atopy |
| title | Fertility Treatment Resulting in Live Births in Women with Asthma – Associated with Perennial Allergy? |
| title_full | Fertility Treatment Resulting in Live Births in Women with Asthma – Associated with Perennial Allergy? |
| title_fullStr | Fertility Treatment Resulting in Live Births in Women with Asthma – Associated with Perennial Allergy? |
| title_full_unstemmed | Fertility Treatment Resulting in Live Births in Women with Asthma – Associated with Perennial Allergy? |
| title_short | Fertility Treatment Resulting in Live Births in Women with Asthma – Associated with Perennial Allergy? |
| title_sort | fertility treatment resulting in live births in women with asthma ndash associated with perennial allergy |
| topic | asthma allergy pregnancy ivf art fertility atopy |
| url | https://www.dovepress.com/fertility-treatment-resulting-in-live-births-in-women-with-asthma-ndas-peer-reviewed-article-JAA |
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