EVALUATION OF THE RADIO-PROTECTIVE EFFECTS OF HIGH CAFFEIC ACID PHENYL ESTER CONTAINING PROPOLIS ON RADIOTHERAPY-MEDIATED BUCCAL MUCOSITIS
Aim of the study Lesions such as intraoral buccal mucositis encountered during radiotherapy after head and neck cancers are challenging regarding the prognosis and patient survival. For this purpose, the effectiveness of propolis containing high caffeic acid phenyl ester on buccal mucositis was inve...
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| Format: | Article |
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Romanian Society of Oral Rehabilitation
2023-03-01
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| Series: | Romanian Journal of Oral Rehabilitation |
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| Online Access: | https://www.rjor.ro/evaluation-of-the-radio-protective-effects-of-high-caffeic-acid-phenyl-ester-containing-propolis-on-radiotherapy-mediated-buccal-mucositis/ |
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| author | Mustafa Sami Demirsoy Aras Erdil Gülhan Güler Avcı Fikret Gevrek |
| author_facet | Mustafa Sami Demirsoy Aras Erdil Gülhan Güler Avcı Fikret Gevrek |
| author_sort | Mustafa Sami Demirsoy |
| collection | DOAJ |
| description | Aim of the study Lesions such as intraoral buccal mucositis encountered during radiotherapy after head and neck cancers are challenging regarding the prognosis and patient survival. For this purpose, the effectiveness of propolis containing high caffeic acid phenyl ester on buccal mucositis was investigated in a rodent model. Material and methods In the study groups, which comprised nine rats each, radiotherapy (15Gy) was delivered to the head and neck regions. In two of the study groups 100 and 200 mg/kg propolis were administered systemically for 14 days. In the harvested buccal mucosa samples, proinflammatory markers (interleukin-6 [IL-6], myeloperoxidase [MPO], tumor-necrosis factor-α [TNF-α]) were analyzed with Enzyme Linked-Immuno-Sorbent Assay method, and tissue samples were stained with Hematoxylin-eosin and classified regarding the inflammation scores. Results The tissue levels of IL-6, MPO, and TNF-α significantly decreased in a dose-dependent manner in experimental groups (P = 0.001, P = 0.016, P = 0.001, respectively). Also, the inflammation scores were highest in Group 2 (P = 0.002), whereas Groups 3 and 4 had the lowest (P = 0.012). Conclusions Aqueous propolis extract containing high caffeic acid phenyl ester can prevent lesions with its superior anti-inflammatory and free radical scavenging properties. The administration of aqueous propolis containing high caffeic acid phenyl ester decreased the inflammatory responses in a dose-dependent manner. |
| first_indexed | 2024-04-09T17:10:40Z |
| format | Article |
| id | doaj.art-c9fc5046f94945688dc6d4906e802741 |
| institution | Directory Open Access Journal |
| issn | 2066-7000 2601-4661 |
| language | English |
| last_indexed | 2024-04-09T17:10:40Z |
| publishDate | 2023-03-01 |
| publisher | Romanian Society of Oral Rehabilitation |
| record_format | Article |
| series | Romanian Journal of Oral Rehabilitation |
| spelling | doaj.art-c9fc5046f94945688dc6d4906e8027412023-04-20T08:06:28ZengRomanian Society of Oral RehabilitationRomanian Journal of Oral Rehabilitation2066-70002601-46612023-03-01151615EVALUATION OF THE RADIO-PROTECTIVE EFFECTS OF HIGH CAFFEIC ACID PHENYL ESTER CONTAINING PROPOLIS ON RADIOTHERAPY-MEDIATED BUCCAL MUCOSITISMustafa Sami Demirsoy0Aras Erdil1Gülhan Güler Avcı2Fikret Gevrek3Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sakarya University, Sakarya, TurkeyDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Uşak University, Uşak, TurkeyDepartment of Radiation Oncology, Faculty of Medicine, Tokat Gaziosmanpaşa University, Tokat, TurkeyDepartment of Histology and Embryology, Faculty of Medicine, Tokat Gaziosmanpaşa University, Tokat, TurkeyAim of the study Lesions such as intraoral buccal mucositis encountered during radiotherapy after head and neck cancers are challenging regarding the prognosis and patient survival. For this purpose, the effectiveness of propolis containing high caffeic acid phenyl ester on buccal mucositis was investigated in a rodent model. Material and methods In the study groups, which comprised nine rats each, radiotherapy (15Gy) was delivered to the head and neck regions. In two of the study groups 100 and 200 mg/kg propolis were administered systemically for 14 days. In the harvested buccal mucosa samples, proinflammatory markers (interleukin-6 [IL-6], myeloperoxidase [MPO], tumor-necrosis factor-α [TNF-α]) were analyzed with Enzyme Linked-Immuno-Sorbent Assay method, and tissue samples were stained with Hematoxylin-eosin and classified regarding the inflammation scores. Results The tissue levels of IL-6, MPO, and TNF-α significantly decreased in a dose-dependent manner in experimental groups (P = 0.001, P = 0.016, P = 0.001, respectively). Also, the inflammation scores were highest in Group 2 (P = 0.002), whereas Groups 3 and 4 had the lowest (P = 0.012). Conclusions Aqueous propolis extract containing high caffeic acid phenyl ester can prevent lesions with its superior anti-inflammatory and free radical scavenging properties. The administration of aqueous propolis containing high caffeic acid phenyl ester decreased the inflammatory responses in a dose-dependent manner.https://www.rjor.ro/evaluation-of-the-radio-protective-effects-of-high-caffeic-acid-phenyl-ester-containing-propolis-on-radiotherapy-mediated-buccal-mucositis/apitherapyradiation therapymucositisinflammation |
| spellingShingle | Mustafa Sami Demirsoy Aras Erdil Gülhan Güler Avcı Fikret Gevrek EVALUATION OF THE RADIO-PROTECTIVE EFFECTS OF HIGH CAFFEIC ACID PHENYL ESTER CONTAINING PROPOLIS ON RADIOTHERAPY-MEDIATED BUCCAL MUCOSITIS Romanian Journal of Oral Rehabilitation apitherapy radiation therapy mucositis inflammation |
| title | EVALUATION OF THE RADIO-PROTECTIVE EFFECTS OF HIGH CAFFEIC ACID PHENYL ESTER CONTAINING PROPOLIS ON RADIOTHERAPY-MEDIATED BUCCAL MUCOSITIS |
| title_full | EVALUATION OF THE RADIO-PROTECTIVE EFFECTS OF HIGH CAFFEIC ACID PHENYL ESTER CONTAINING PROPOLIS ON RADIOTHERAPY-MEDIATED BUCCAL MUCOSITIS |
| title_fullStr | EVALUATION OF THE RADIO-PROTECTIVE EFFECTS OF HIGH CAFFEIC ACID PHENYL ESTER CONTAINING PROPOLIS ON RADIOTHERAPY-MEDIATED BUCCAL MUCOSITIS |
| title_full_unstemmed | EVALUATION OF THE RADIO-PROTECTIVE EFFECTS OF HIGH CAFFEIC ACID PHENYL ESTER CONTAINING PROPOLIS ON RADIOTHERAPY-MEDIATED BUCCAL MUCOSITIS |
| title_short | EVALUATION OF THE RADIO-PROTECTIVE EFFECTS OF HIGH CAFFEIC ACID PHENYL ESTER CONTAINING PROPOLIS ON RADIOTHERAPY-MEDIATED BUCCAL MUCOSITIS |
| title_sort | evaluation of the radio protective effects of high caffeic acid phenyl ester containing propolis on radiotherapy mediated buccal mucositis |
| topic | apitherapy radiation therapy mucositis inflammation |
| url | https://www.rjor.ro/evaluation-of-the-radio-protective-effects-of-high-caffeic-acid-phenyl-ester-containing-propolis-on-radiotherapy-mediated-buccal-mucositis/ |
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